ZFIN ID: ZDB-GENE-040426-747
Gene Name: lin-28 homolog A (C. elegans)
Gene Symbol: lin28a    Nomenclature History

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Previous Names: lin28, sb:cb650, zgc:55584 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have RNA binding activity and polysome binding activity. Involved in chordate embryonic development; negative regulation of gene expression; and regeneration. Predicted to localize to cytoplasmic ribonucleoprotein granule; nucleus; and polysome. Is expressed in several structures, including Kupffer's vesicle; central nervous system; digestive system; neural plate; and neural tube. Orthologous to human LIN28A (lin-28 homolog A).
Genome Resources: Alliance (1),  Gene:394066 (1),  Ensembl(GRCz11):ENSDARG00000016999 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013377Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la020599Tg Transgenic Insertion Unknown Unknown DNA
    la020600Tg Transgenic Insertion Unknown Unknown DNA
    la020601Tg Transgenic Insertion Unknown Unknown DNA
    la027996Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-lin28a
    2
    MO1-lin28a N/A 4
    MO2-lin28a N/A 5
    MO3-lin28a N/A 1
    MO4-lin28a N/A 1
    DISEASE ASSOCIATED WITH lin28a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH lin28a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chordate embryonic development (more)
    Cellular Component cytoplasmic stress granule (more)
    Molecular Function polysome binding (more)
    GO Terms (all 22)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lin28a-001 (1)    Ensembl 2020
    lin28a-202 (1)    Ensembl 494
    lin28a-203 (1)    Ensembl 607
    lin28a-204 (1)    Ensembl 547
    lin28a-206 (1)    Ensembl 908
    ncRNA lin28a-005 (1)    Ensembl 793
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM lin28a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:MYC-lin28a,-1.0Cau.Tuba1:GFP) hsp70l GFPlin28aMYC Carassius auratusDanio rerio 1 1
    MARKER RELATIONSHIPS
    lin28a Contained in: [BAC] CH211-232D9 (1)
    lin28a Encodes: [EST] cb650 (1) (order this)
    [cDNA] MGC:55584 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201091 (1) 1692 nt
    Genomic GenBank:BX322664 (1) 157585 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8Q8W5 (1) 207 aa
    Sequence Information (all 22)
    ORTHOLOGY for lin28a ( Chr: 19 )
    CITATIONS (54)