Gene

irak4

ID
ZDB-GENE-040426-738
Name
interleukin-1 receptor-associated kinase 4
Symbol
irak4 Nomenclature History
Previous Names
  • zgc:55553
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in positive regulation of transcription, DNA-templated and response to bacterium. Predicted to localize to cytoplasm. Is expressed in brain; gill; heart; immune system; and liver. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human IRAK4 (interleukin 1 receptor associated kinase 4).
Genome Resources
Note
None
Expression
All Expression Data
5 figures from 3 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With irak4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Immunodeficiency 67 607676
Associated With irak4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR037970 IRAK4, Death domain
Family IPR017428 Interleukin-1 receptor-associated kinase 4
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR011029 Death-like domain superfamily
Domain Details Per Protein
Protein Length Death-like domain superfamily Interleukin-1 receptor-associated kinase 4 IRAK4, Death domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain
UniProtKB:A0A0R4IP49 481
UniProtKB:A0A0R4IQ44 447
UniProtKB:A0A0R4IF68 382
UniProtKB:Q6IWL3 483
UniProtKB:Q7ZVW7 382
Transcripts
Genome Browsers
No data available
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations