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ZIRC
ZFIN ID: ZDB-GENE-040426-738
Gene Name: interleukin-1 receptor-associated kinase 4
Gene Symbol: irak4    Nomenclature History

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Previous Name: zgc:55553

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in positive regulation of transcription, DNA-templated and response to bacterium. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in brain; gill; heart; immune system; and liver. Orthologous to human IRAK4 (interleukin 1 receptor associated kinase 4).
Genome Resources: Alliance (1),  Gene:393132 (1),  Ensembl(GRCz11):ENSDARG00000100534 (1)
GENE EXPRESSION
All Expression Data: 5 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7161258]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014795Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32505 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-irak4 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH irak4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Invasive pneumococcal disease, recurrent isolated, 1 610799
    IRAK4 deficiency 607676
    DISEASE ASSOCIATED WITH irak4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of transcription, DNA-templated (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 15)
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM irak4 No data available
    MARKER RELATIONSHIPS
    irak4 Encodes: [EST] IMAGE:7161258 (1) (order this)
    [cDNA] MGC:55553 (1) (order this), MGC:191952 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200163 (1)
    Genomic GenBank:CABZ01095583 (1) 12671 bp
    Polypeptide UniProtKB:Q6IWL3 (1) 483 aa
    Sequence Clusters UniGene:81680 (1)
    Sequence Information (all 22)
    ORTHOLOGY for irak4 ( Chr: 25 )
    CITATIONS (33)