Gene

irak4

ID

ZDB-GENE-040426-738

Name

interleukin-1 receptor-associated kinase 4

Symbol

irak4 Nomenclature History

Previous Names

zgc:55553

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in positive regulation of transcription, DNA-templated and response to bacterium. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in brain; gill; heart; immune system; and liver. Orthologous to human IRAK4 (interleukin 1 receptor associated kinase 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7161258 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With irak4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Immunodeficiency 67	607676

Associated With irak4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR037970	IRAK4, Death domain
Family	IPR017428	Interleukin-1 receptor-associated kinase 4
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR011029	Death-like domain superfamily

Domain Details Per Protein

Protein	Length	Death-like domain superfamily	Interleukin-1 receptor-associated kinase 4	IRAK4, Death domain	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine-threonine/tyrosine-protein kinase, catalytic domain
UniProtKB:A0A0R4IP49 InterPro	481
UniProtKB:A0A0R4IQ44 InterPro	447
UniProtKB:A0A0R4IF68 InterPro	382
UniProtKB:Q7ZVW7 InterPro	382

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	irak4-201 (1) Ensembl	Ensembl		1,351 nt	Select Tool ZFIN BLAST
mRNA	irak4-202 (1) Ensembl	Ensembl		1,341 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations