ZFIN Gene: pdia2

ZFIN ID: ZDB-GENE-040426-705

ZFIN ID: ZDB-GENE-040426-705

Gene Name:

protein disulfide isomerase family A, member 2

Gene Symbol:

pdia2 Nomenclature History

Previous Name:

zgc:55398 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 1 Mapping Details/Browsers

Description:

Predicted to have protein disulfide isomerase activity. Predicted to be involved in protein folding and response to endoplasmic reticulum stress. Predicted to localize to endoplasmic reticulum. Is expressed in pancreas and pancreatic bud. Orthologous to human PDIA2 (protein disulfide isomerase family A member 2).

Genome Resources:

Alliance (1), Gene:394023 (1), Ensembl(GRCz11):ENSDARG00000018263 (2)

GENE EXPRESSION
Directly Submitted Expression Data:	3 figures (4 images) from Thisse et al., 2004 [MGC:55398]
Wild-type Stages, Structures:	Pharyngula:High-pec (42.0h-48.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
	pancreas pancreatic bud
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa10302	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa12819	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa13027	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa15452	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa19434	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa31193	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa32599	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
zko204a	Small Deletion	Unknown	Unknown	CRISPR	China Zebrafish Resource Center (CZRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-pdia2	zko204a	1

PHENOTYPE No data available

DISEASE ASSOCIATED WITH pdia2 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH pdia2 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	cell redox homeostasis (more)
Cellular Component	endoplasmic reticulum (more)
Molecular Function	isomerase activity (more)

GO Terms (all 6)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	pdia2-201 (1)	1845	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM pdia2 No data available

MARKER RELATIONSHIPS

pdia2 Contained in:	[BAC] DKEYP-75B4 (1)
pdia2 Encodes:	[cDNA] MGC:55398 (1), MGC:191803 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_201048 (1)	1849 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX548256 (1)	181272 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:B8A5M6 (1)	555 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 15)

ORTHOLOGY for pdia2 ( Chr: 1 )

CITATIONS (22)

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