Gene

nup133

ID

ZDB-GENE-040426-2941

Name

nucleoporin 133

Symbol

nup133 Nomenclature History

Previous Names

wu:fa04e09
zgc:55311

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to be a structural constituent of nuclear pore. Predicted to be involved in several processes, including nuclear pore distribution; nucleocytoplasmic transport; and transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery. Predicted to colocalize with condensed chromosome kinetochore. Used to study Galloway-Mowat syndrome. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome and nephrotic syndrome type 18. Is expressed in several structures, including heart; integument; liver; nervous system; and pleuroperitoneal region. Orthologous to human NUP133 (nucleoporin 133).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nup133 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
nephrotic syndrome type 18	Alliance	Nephrotic syndrome, type 18	618177
		?Galloway-Mowat syndrome 8	618349

Associated With nup133 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Galloway-Mowat syndrome 1	WT + MO1-nup133	standard conditions	Fujita et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR007187	Nucleoporin, Nup133/Nup155-like, C-terminal
Domain	IPR014908	Nucleoporin, Nup133/Nup155-like, N-terminal
Family	IPR037624	Nuclear pore complex protein Nup133-like
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily