ZFIN ID: ZDB-GENE-040426-2941
Gene Name: nucleoporin 133
Gene Symbol: nup133    Nomenclature History

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Previous Names: wu:fa04e09, zgc:55311

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to be a structural constituent of nuclear pore. Predicted to be involved in several processes, including nuclear pore distribution; nucleocytoplasmic transport; and transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery. Predicted to colocalize with condensed chromosome kinetochore. Is expressed in several structures, including heart; integument; liver; nervous system; and pleuroperitoneal region. Used to study Galloway-Mowat syndrome 1. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome and nephrotic syndrome type 18. Orthologous to human NUP133 (nucleoporin 133).
Genome Resources: Alliance (1),  Gene:406852 (1),  Ensembl(GRCz11):ENSDARG00000010078 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013731Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18482 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko1074a Small Deletion Unknown Unknown CRISPR
    zko1074b Indel Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-nup133 1
    MO1-nup133 N/A 1
    MO2-nup133 N/A 1
    MO3-nup133 N/A 1
    DISEASE ASSOCIATED WITH nup133 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    nephrotic syndrome type 18 Alliance Nephrotic syndrome, type 18 618177
    ?Galloway-Mowat syndrome 8 618349
    DISEASE ASSOCIATED WITH nup133 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    Galloway-Mowat syndrome 1 WT + MO1-nup133 standard conditions Fujita et al., 2018
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process mRNA transport (more)
    Cellular Component chromosome (more)
    Molecular Function structural constituent of nuclear pore (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nup133-201 (1)    Ensembl 3659
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nup133 No data available
    MARKER RELATIONSHIPS
    nup133 Contained in: [BAC] CH211-52O18 (1), CH211-133L11 (1)
    nup133 Encodes: [EST] fa04e09 (1)
    [cDNA] MGC:55311 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213531 (1) 3679 nt
    Genomic GenBank:AL929114 (1) 180158 nt
    Select Tool
    Polypeptide UniProtKB:F1QNV4 (1) 1136 aa
    Sequence Information (all 12)
    ORTHOLOGY for nup133 ( Chr: 1 )
    CITATIONS (29)