ZFIN ID: ZDB-GENE-040426-2855
Gene Name: guanine nucleotide binding protein (G protein), beta polypeptide 1b
Gene Symbol: gnb1b    Nomenclature History

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Previous Names: gnb1l (1), GNB1x (1), fb39f01, wu:fb39f01, wu:fb98e06, wu:fj09d12, zgc:55774

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have G-protein gamma-subunit binding activity. Involved in positive regulation of neutrophil migration and posterior lateral line neuromast primordium migration. Predicted to localize to cytoplasm and heterotrimeric G-protein complex. Is expressed in blastomere; female organism; head; and lateral line system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia and autosomal dominant non-syndromic intellectual disability 42. Orthologous to human GNB1 (G protein subunit beta 1).
Genome Resources: Alliance (1),  Gene:406796 (1),  Ensembl(GRCz11):ENSDARG00000104372 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la029252Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-gnb1b N/A 2
    MO2-gnb1b N/A 3
    MO3-gnb1b N/A 2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gnb1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acute lymphoblastic leukemia Alliance Leukemia, acute lymphoblastic, somatic 613065
    autosomal dominant non-syndromic intellectual disability 42 Alliance Mental retardation, autosomal dominant 42 616973
    DISEASE ASSOCIATED WITH gnb1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of neutrophil migration (more)
    Cellular Component cytoplasm (more)
    Molecular Function protein binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gnb1b-201 (1)    Ensembl 2049
    gnb1b-202 (1)    Ensembl 3891
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gnb1b No data available
    MARKER RELATIONSHIPS
    gnb1b Contained in: [BAC] CH211-161C3 (1)
    gnb1b Encodes: [EST] fb39f01, fb98e06 (order this), fj09d12
    [cDNA] MGC:55774 (1), MGC:174133 (1), MGC:191318 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213481 (1) 2553 nt
    Genomic GenBank:CR854824 (1) 122862 nt
    Select Tool
    Polypeptide UniProtKB:Q803H5 (1) 340 aa
    Sequence Information (all 27)
    ORTHOLOGY for gnb1b ( Chr: 6 )
    CITATIONS (44)