ZFIN ID: ZDB-GENE-040426-2747
Gene Name: PR domain containing 8
Gene Symbol: prdm8    Nomenclature History

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Previous Names: wu:fd12b11, zgc:63680

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have metal ion binding activity and nucleic acid binding activity. Predicted to be involved in oligodendrocyte development. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy. Is expressed in nervous system; neural plate; and neural tube. Orthologous to several human genes including ZNF488 (zinc finger protein 488).
Genome Resources: Alliance (1),  Gene:406719 (1),  Ensembl(GRCz11):ENSDARG00000025017 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa31938 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-prdm8 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH prdm8 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    progressive myoclonus epilepsy 10 Alliance ?Epilepsy, progressive myoclonic, 10 616640
    DISEASE ASSOCIATED WITH prdm8 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001214 SET domain
    Domain IPR013087 Zinc finger C2H2-type
    Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA prdm8-201 (1)    Ensembl 2351
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM prdm8 No data available
    MARKER RELATIONSHIPS
    prdm8 Contained in: [BAC] CH211-134J6 (1)
    prdm8 Encodes: [EST] fd12b11 (1), IMAGE:7137167 (1), IMAGE:7158686 (1)
    [cDNA] MGC:63680 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213410 (1) 2365 nt
    Genomic GenBank:BX855615 (1) 92637 nt
    Select Tool
    Polypeptide UniProtKB:B8A5Y1 (1) 502 aa
    Sequence Information (all 15)
    ORTHOLOGY for prdm8 ( Chr: 13 )
    CITATIONS (20)