Gene

smurf1

ID
ZDB-GENE-040426-2744
Name
SMAD specific E3 ubiquitin protein ligase 1
Symbol
smurf1 Nomenclature History
Previous Names
  • wu:fb30b12
  • wwp1
  • zgc:66401
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of BMP signaling pathway; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to localize to cytoplasm. Is expressed in alar plate midbrain region; axis; midbrain; neural plate; and notochord. Orthologous to human SMURF1 (SMAD specific E3 ubiquitin protein ligase 1).
Genome Resources
Note
None
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With smurf1 Human Ortholog
No data available
Associated With smurf1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000008 C2 domain
Domain IPR000569 HECT domain
Domain IPR001202 WW domain
Family IPR024928 E3 ubiquitin-protein ligase, SMURF1 type
Homologous_superfamily IPR035892 C2 domain superfamily
Homologous_superfamily IPR035983 HECT, E3 ligase catalytic domain
Homologous_superfamily IPR036020 WW domain superfamily
Domain Details Per Protein
Protein Length C2 domain C2 domain superfamily E3 ubiquitin-protein ligase, SMURF1 type HECT domain HECT, E3 ligase catalytic domain WW domain WW domain superfamily
UniProtKB:Q6PCR3 731
UniProtKB:F1QEG9 731
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations