ZFIN ID: ZDB-GENE-040426-2703
Gene Name: glutamic-oxaloacetic transaminase 2a, mitochondrial
Gene Symbol: got2a    Nomenclature History

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Previous Names: got2 (1), zgc:66329

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have L-aspartate:2-oxoglutarate aminotransferase activity. Predicted to be involved in aspartate catabolic process. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy. Orthologous to human GOT2 (glutamic-oxaloacetic transaminase 2).
Genome Resources: Alliance (1),  Gene:406688 (1),  Ensembl(GRCz11):ENSDARG00000041068 (1)
GENE EXPRESSION
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-got2a N/A 1
MO2-got2a N/A 1
DISEASE ASSOCIATED WITH got2a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Epileptic encephalopathy, early infantile, 82 618721
DISEASE ASSOCIATED WITH got2a VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
early infantile epileptic encephalopathy WT + MO1-got2a standard conditions van Karnebeek et al., 2019
GENE ONTOLOGY
Ontology GO Term
Biological Process biosynthetic process (more)
Cellular Component membrane (more)
Molecular Function catalytic activity (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA got2a-201 (1)    Ensembl 2573
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM got2a No data available
MARKER RELATIONSHIPS
got2a Contained in: [BAC] DKEY-12E7 (1) (order this)
got2a Encodes: [cDNA] MGC:66329 (1), MGC:192891 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_213379 (1) 2459 nt
Genomic GenBank:BX571884 (1) 101906 nt
Select Tool
Polypeptide UniProtKB:Q7SYK7 (1) 428 aa
Sequence Information (all 16)
ORTHOLOGY for got2a ( Chr: 18 )
CITATIONS (29)