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ZIRC
ZFIN ID: ZDB-GENE-040426-2674
Gene Name: GRB2-associated binding protein 1
Gene Symbol: gab1    Nomenclature History

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Previous Names: fb11b01, fc66d01, wu:fb11b01, wu:fc66d01, zgc:56412 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Involved in epiboly. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 26. Is expressed in brain and inner ear. Orthologous to human GAB1 (GRB2 associated binding protein 1).
Genome Resources: Alliance (1),  Gene:406666 (1),  Ensembl(GRCz11):ENSDARG00000037018 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:56412]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la021142Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32710 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko663a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-gab1 1
    MO1-gab1 N/A 1
    MO2-gab1 N/A 1
    DISEASE ASSOCIATED WITH gab1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive nonsyndromic deafness 26 Alliance ?Deafness, autosomal recessive 26 605428
    DISEASE ASSOCIATED WITH gab1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process epiboly (more)
    Cellular Component cellular_component (more)
    GO Terms (all 2)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001849 (1)
  • InterPro:IPR011993 (1)
  • PROSITE:PS50003 (1)
  • Pfam:PF00169 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gab1-202 (1)    Ensembl 4453
    ncRNA gab1-003 (1) 1209
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gab1 No data available
    MARKER RELATIONSHIPS
    gab1 Contained in: [BAC] CH73-355B6 (1) (order this), DKEY-20H20 (1) (order this), DKEY-27H10 (1) (order this)
    gab1 Encodes: [EST] fb11b01, fc66d01
    [cDNA] MGC:56412 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213357 (1) 1865 bp
    Genomic GenBank:BX322570 (1) 185032 bp
    Select Tool
    Polypeptide UniProtKB:F1Q7S5 (1) 740 aa
    Sequence Clusters UniGene:159598 (1)
    Sequence Information (all 42)
    ORTHOLOGY for gab1 ( Chr: 1 )
    CITATIONS (24)