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Gene

ddc

ID
ZDB-GENE-040426-2656
Name
dopa decarboxylase
Symbol
ddc Nomenclature History
Previous Names
  • aromatic amino acid decarboxylase (1)
  • wu:fa56d05
  • wu:fd59h03
  • wu:fk20h01
  • zgc:65801 (1)
  • zgc:76929 (1)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to enable aromatic-L-amino-acid decarboxylase activity. Acts upstream of or within brain development. Predicted to be active in cytoplasm. Is expressed in digestive system; muscle; nervous system; ovary; and pharyngeal arch. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; and inherited metabolic disorder. Orthologous to human DDC (dopa decarboxylase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
16 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Shih et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ddc Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
aromatic L-amino acid decarboxylase deficiency Alliance Aromatic L-amino acid decarboxylase deficiency 608643
Associated With ddc Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR021115 Pyridoxal-phosphate binding site
Family IPR002129 Pyridoxal phosphate-dependent decarboxylase
Family IPR010977 Aromatic-L-amino-acid decarboxylase
Homologous_superfamily IPR015421 Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily IPR015422 Pyridoxal phosphate-dependent transferase domain 1
Homologous_superfamily IPR015424 Pyridoxal phosphate-dependent transferase
Domain Details Per Protein
Protein Length Aromatic-L-amino-acid decarboxylase Pyridoxal-phosphate binding site Pyridoxal phosphate-dependent decarboxylase Pyridoxal phosphate-dependent transferase Pyridoxal phosphate-dependent transferase domain 1 Pyridoxal phosphate-dependent transferase, major domain
UniProtKB:Q7SZR0 480
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations