ZFIN ID: ZDB-GENE-040426-2656
Gene Name: dopa decarboxylase
Gene Symbol: ddc    Nomenclature History

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Previous Names: aromatic amino acid decarboxylase (1), wu:fa56d05, wu:fd59h03, wu:fk20h01, zgc:65801 (1), zgc:76929 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have aromatic-L-amino-acid decarboxylase activity. Involved in brain development. Predicted to localize to cytoplasm. Is expressed in digestive system; muscle; nervous system; ovary; and pharyngeal arch. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; and inherited metabolic disorder. Orthologous to human DDC (dopa decarboxylase).
Genome Resources: Alliance (1),  Gene:406651 (1),  Ensembl(GRCz11):ENSDARG00000016494 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa36042 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ddc N/A 1
    MO2-ddc N/A 1
    DISEASE ASSOCIATED WITH ddc HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    aromatic L-amino acid decarboxylase deficiency Alliance Aromatic L-amino acid decarboxylase deficiency 608643
    DISEASE ASSOCIATED WITH ddc VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process brain development (more)
    Cellular Component cytoplasm (more)
    Molecular Function carboxy-lyase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ddc-201 (1)    Ensembl 4117
    ncRNA ddc-002 (1)    Ensembl 814
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ddc No data available
    MARKER RELATIONSHIPS
    ddc Contained in: [BAC] CH211-149M3 (1)
    ddc Contains: [STS] chunp30644
    ddc Encodes: [EST] fa56d05 (1), fd59h03 (1), fk20h01 (1)
    [cDNA] MGC:65801 (1), MGC:76929
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213342 (1) 4136 nt
    Genomic GenBank:CR478208 (1) 195111 nt
    Select Tool
    Polypeptide UniProtKB:Q7SZR0 (1) 480 aa
    Sequence Information (all 16)
    ORTHOLOGY for ddc ( Chr: 16 )
    CITATIONS (40)