ZFIN ID: ZDB-GENE-040426-2653
Gene Name: palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)
Gene Symbol: ppt1    Nomenclature History

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Previous Names: wu:fj17f04, zgc:63969

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have palmitoyl-(protein) hydrolase activity. Predicted to be involved in protein depalmitoylation and receptor-mediated endocytosis. Predicted to localize to lysosome. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 1. Orthologous to human PPT1 (palmitoyl-protein thioesterase 1).
Genome Resources: Alliance (1),  Gene:406648 (1),  Ensembl(GRCz11):ENSDARG00000039980 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:63969]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23590 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ppt1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    neuronal ceroid lipofuscinosis 1 Alliance Ceroid lipofuscinosis, neuronal, 1 256730
    DISEASE ASSOCIATED WITH ppt1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein depalmitoylation (more)
    Cellular Component intracellular membrane-bounded organelle (more)
    Molecular Function palmitoyl hydrolase activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ppt1-201 (1)    Ensembl 1609
    ppt1-203 (1)    Ensembl 800
    ppt1-204 (1)    Ensembl 836
    ncRNA ppt1-002 (1)    Ensembl 904
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ppt1 No data available
    MARKER RELATIONSHIPS
    ppt1 Contained in: [Fosmid] CH1073-365B9 (1), CH1073-513E17 (1)
    ppt1 Encodes: [EST] fj17f04 (1)
    [cDNA] MGC:63969 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213339 (1) 1549 nt
    Genomic GenBank:CU611043 (1) 34732 nt
    Select Tool
    Polypeptide UniProtKB:F1R8J6 (1) 303 aa
    Sequence Information (all 21)
    ORTHOLOGY for ppt1 ( Chr: 19 )
    CITATIONS (25)