Gene
eif2b2
- ID
- ZDB-GENE-040426-2605
- Name
- eukaryotic translation initiation factor 2B, subunit 2 beta
- Symbol
- eif2b2 Nomenclature History
- Previous Names
-
- zgc:77512
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of translational initiation and translational initiation. Predicted to localize to eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B2 (eukaryotic translation initiation factor 2B subunit beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Keefe et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Keefe et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| leukoencephalopathy with vanishing white matter 2 | Alliance | Leukoencephalopathy with vanishing white matter 2, with or without ovarian failure | 620312 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Initiation factor 2B-like, C-terminal | Initiation factor 2B-related | NagB/RpiA transferase-like |
|---|---|---|---|---|
|
UniProtKB:Q6NXC7
|
355 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
eif2b2-201
(1)
|
Havana | 1247 nt |
Interactions and Pathways
No data available
Plasmids
No data available