ZFIN ID: ZDB-GENE-040426-2605
Gene Name: eukaryotic translation initiation factor 2B, subunit 2 beta
Gene Symbol: eif2b2    Nomenclature History

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Previous Name: zgc:77512

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of translational initiation and translational initiation. Predicted to localize to eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B2 (eukaryotic translation initiation factor 2B subunit beta).
Genome Resources: Alliance (1),  Gene:405839 (1),  Ensembl(GRCz11):ENSDARG00000041397 (1)
GENE EXPRESSION
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa17223 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH eif2b2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    leukoencephalopathy with vanishing white matter Alliance Leukoencephalopathy with vanishing white matter 603896
    Ovarioleukodystrophy 603896
    DISEASE ASSOCIATED WITH eif2b2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular metabolic process (more)
    Cellular Component eukaryotic translation initiation factor 2B complex (more)
    Molecular Function translation initiation factor activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA eif2b2-201 (1)    Ensembl 1247
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM eif2b2 No data available
    MARKER RELATIONSHIPS
    eif2b2 Contained in: [BAC] DKEY-199I12 (1) (order this)
    eif2b2 Encodes: [cDNA] MGC:77512 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212903 (1) 1211 nt
    Genomic GenBank:BX936455 (1) 123707 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4ITG6 (1) 359 aa
    Sequence Information (all 8)
    ORTHOLOGY for eif2b2 ( Chr: 20 )
    CITATIONS (20)