ZFIN ID: ZDB-GENE-040426-2592
Gene Name: nicotinamide nucleotide transhydrogenase
Gene Symbol: nnt    Nomenclature History

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Previous Names: wu:fa20d10, wu:fc86a04, zgc:76979

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have NAD binding activity; NAD(P)+ transhydrogenase activity; and NADP binding activity. Predicted to be involved in NADPH regeneration. Predicted to localize to mitochondrion. Is expressed in female organism. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human NNT (nicotinamide nucleotide transhydrogenase).
Genome Resources: Alliance (1),  Gene:406619 (1),  Ensembl(GRCz11):ENSDARG00000023536 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6912632]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa39325 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-nnt N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH nnt HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Glucocorticoid deficiency 4, with or without mineralocorticoid deficiency 614736
    DISEASE ASSOCIATED WITH nnt VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process oxidation-reduction process (more)
    Cellular Component integral component of membrane (more)
    Molecular Function NAD(P)+ transhydrogenase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nnt-201 (1)    Ensembl 4734
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nnt No data available
    MARKER RELATIONSHIPS
    nnt Contained in: [BAC] CH211-147J13 (1), CH211-284A17 (1)
    nnt Encodes: [EST] fa20d10 (1), fc86a04 (1), IMAGE:6912632 (1)
    [cDNA] MGC:76979 (1), MGC:174430 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_214756 (1) 4750 nt
    Genomic GenBank:BX927162 (1) 90057 nt
    Select Tool
    Polypeptide UniProtKB:Q6NYQ7 (1) 1079 aa
    Sequence Information (all 20)
    ORTHOLOGY for nnt ( Chr: 21 )
    CITATIONS (28)