ZFIN ID: ZDB-GENE-040426-2587
Gene Name: interferon regulatory factor 5
Gene Symbol: irf5    Nomenclature History

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Previous Names: im:7155364, zgc:76986

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in immune system process. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in inflammatory bowel disease 14 and systemic lupus erythematosus. Is expressed in several structures, including gill; heart; immune system; liver; and muscle. Orthologous to human IRF5 (interferon regulatory factor 5).
Genome Resources: Alliance (1),  Gene:405811 (1),  Ensembl(GRCz11):ENSDARG00000045681 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7155364]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH irf5 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
inflammatory bowel disease 14 Alliance {Inflammatory bowel disease 14} 612245
{Systemic lupus erythematosus, susceptibility to, 10} 612251
DISEASE ASSOCIATED WITH irf5 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cytokine-mediated signaling pathway (more)
Cellular Component nucleus (more)
Molecular Function DNA-binding transcription factor activity (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR001346 Interferon regulatory factor DNA-binding domain
Homologous_superfamily IPR008984 SMAD/FHA domain superfamily
Homologous_superfamily IPR017855 SMAD-like domain superfamily
Domain IPR019471 Interferon regulatory factor-3
Conserved_site IPR019817 Interferon regulatory factor, conserved site
Family IPR029838 Interferon regulatory factor 5
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA irf5-201 (1)    Ensembl 1551
irf5-204 (1)    Ensembl 548
ncRNA irf5-003 (1)    Ensembl 2536
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM irf5 No data available
MARKER RELATIONSHIPS
irf5 Contained in: [BAC] CH211-266A5 (1)
irf5 Encodes: [EST] IMAGE:7155364 (1)
[cDNA] MGC:76986 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_212875 (1) 2560 bp
Genomic GenBank:BX465210 (1) 171708 bp
Select Tool
Polypeptide UniProtKB:B0S682 (1) 516 aa
Sequence Information (all 15)
ORTHOLOGY for irf5 ( Chr: 4 )
CITATIONS (31)