ZFIN ID: ZDB-GENE-040426-2575
Gene Name: catenin, beta 2
Gene Symbol: ctnnb2    Nomenclature History

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Previous Names: ich, wu:fa12h09, wu:fc16f05, zgc:65770

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have several functions, including alpha-catenin binding activity; cadherin binding activity; and transcription coactivator activity. Involved in canonical Wnt signaling pathway; convergent extension; and dorsal/ventral pattern formation. Localizes to nucleus. Is expressed in corneal endothelium; interneuromast cell; neuromast; and secondary posterior lateral line primordium. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant non-syndromic intellectual disability 19; exudative vitreoretinopathy 7; hepatocellular carcinoma (multiple); medulloblastoma; and pilomatrixoma. Orthologous to human CTNNB1 (catenin beta 1).
Genome Resources: Alliance (1),  Gene:324004 (1),  Ensembl(GRCz11):ENSDARG00000023472 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 4 publications
Wild-type Stages, Structures: Blastula:Sphere (4.0h-4.33h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ctnnb2_unspecified Unspecified Unknown Unknown
p1 Unknown Unknown Unknown
sa23605 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43353 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ctnnb2 N/A 19
    MO2-ctnnb2 N/A 2
    MO3-ctnnb2 N/A 4
    DISEASE ASSOCIATED WITH ctnnb2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant non-syndromic intellectual disability 19 Alliance Neurodevelopmental disorder with spastic diplegia and visual defects 615075
    colorectal cancer Alliance Colorectal cancer, somatic 114500
    exudative vitreoretinopathy 7 Alliance Exudative vitreoretinopathy 7 617572
    hepatocellular carcinoma Alliance Hepatocellular carcinoma, somatic 114550
    medulloblastoma Alliance Medulloblastoma, somatic 155255
    ovarian cancer Alliance Ovarian cancer, somatic 167000
    pilomatrixoma Alliance Pilomatricoma, somatic 132600
    DISEASE ASSOCIATED WITH ctnnb2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process canonical Wnt signaling pathway (more)
    Cellular Component nucleus (more)
    Molecular Function protein binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ctnnb2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:ctnnb2-GFP) hsp70l ctnnb2GFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    ctnnb2 Contains: [SNP] rs3729004 (1), rs3729005 (1), rs3729006 (1)
    ctnnb2 Encodes: [EST] fa12h09 (1), fc16f05
    [cDNA] MGC:65770 (1)
    ctnnb2 Has Artifact: [EST] fd20a06 (1)
    [cDNA] MGC:56232
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001001889 (1) 3550 nt
    Polypeptide UniProtKB:E7FC99 (1) 778 aa
    Sequence Information (all 20)
    ORTHOLOGY for ctnnb2 ( Chr: 19 )
    CITATIONS (78)