Gene

ctnnb2

ID
ZDB-GENE-040426-2575
Name
catenin, beta 2
Symbol
ctnnb2 Nomenclature History
Previous Names
  • ich
  • wu:fa12h09
  • wu:fc16f05
  • zgc:65770
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to have several functions, including alpha-catenin binding activity; cadherin binding activity; and transcription coactivator activity. Involved in canonical Wnt signaling pathway; convergent extension; and dorsal/ventral pattern formation. Localizes to nucleus. Is expressed in corneal endothelium; interneuromast cell; neuromast; and secondary posterior lateral line primordium. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant non-syndromic intellectual disability 19; exudative vitreoretinopathy 7; hepatocellular carcinoma (multiple); nephroblastoma; and pilomatrixoma. Orthologous to human CTNNB1 (catenin beta 1).
Genome Resources
Note
None
Expression
All Expression Data
7 figures from 5 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
25 figures from 13 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ctnnb2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant non-syndromic intellectual disability 19 Alliance Neurodevelopmental disorder with spastic diplegia and visual defects 615075
colorectal cancer Alliance Colorectal cancer, somatic 114500
exudative vitreoretinopathy 7 Alliance Exudative vitreoretinopathy 7 617572
hepatocellular carcinoma Alliance Hepatocellular carcinoma, somatic 114550
medulloblastoma Alliance Medulloblastoma, somatic 155255
ovarian cancer Alliance Ovarian cancer, somatic 167000
pilomatrixoma Alliance Pilomatricoma, somatic 132600
Associated With ctnnb2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR013284 Beta-catenin
Homologous_superfamily IPR011989 Armadillo-like helical
Homologous_superfamily IPR016024 Armadillo-type fold
Repeat IPR000225 Armadillo
Domain Details Per Protein
Protein Length Armadillo Armadillo-like helical Armadillo-type fold Beta-catenin
UniProtKB:Q8JID2 778
UniProtKB:Q24JW3 416
UniProtKB:E7FC99 778
UniProtKB:A4QN53 284
Transcripts
Genome Browsers
No data available
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations