ZFIN ID: ZDB-GENE-040426-2574
Gene Name: interferon regulatory factor 2 binding protein 2b
Gene Symbol: irf2bp2b    Nomenclature History

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Previous Names: irf2bp2, wu:fa12b04, wu:fb73g01, zgc:63864

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have transcription corepressor activity and ubiquitin protein ligase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Is expressed in several structures, including immature eye; musculature system; nervous system; notochord; and pronephric duct. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human IRF2BP2 (interferon regulatory factor 2 binding protein 2).
Genome Resources: Alliance (1),  Gene:406614 (1),  Ensembl(GRCz11):ENSDARG00000098635 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa10664 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35166 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-irf2bp2b N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH irf2bp2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Immunodeficiency, common variable, 14 617765
    DISEASE ASSOCIATED WITH irf2bp2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription by RNA polymerase II (more)
    Cellular Component nucleus (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA irf2bp2b-201 (1)    Ensembl 2117
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM irf2bp2b No data available
    MARKER RELATIONSHIPS
    irf2bp2b Contained in: [BAC] CH211-113I9 (1)
    irf2bp2b Encodes: [EST] fa12b04 (1), fb73g01 (1)
    [cDNA] MGC:63864 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_214752 (1) 2142 nt
    Genomic GenBank:BX569779 (1) 182464 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4ITA7 (1) 501 aa
    Sequence Information (all 13)
    ORTHOLOGY for irf2bp2b ( Chr: 11 )
    CITATIONS (22)