Gene

rnf170

ID
ZDB-GENE-040426-2572
Name
ring finger protein 170
Symbol
rnf170 Nomenclature History
Previous Names
  • zgc:65779
  • zgc:76995 (1)
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have metal ion binding activity and ubiquitin protein ligase activity. Involved in chordate embryonic development. Predicted to localize to endoplasmic reticulum; endoplasmic reticulum membrane; and integral component of membrane. Human ortholog(s) of this gene implicated in autosomal dominant sensory ataxia 1. Orthologous to human RNF170 (ring finger protein 170).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rnf170 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant sensory ataxia 1 Alliance Ataxia, sensory, 1, autosomal dominant 608984
hereditary spastic paraplegia 85 Alliance Spastic paraplegia 85, autosomal recessive 619686
Associated With rnf170 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017907 Zinc finger, RING-type, conserved site
Domain IPR001841 Zinc finger, RING-type
Domain IPR010652 Domain of unknown function DUF1232
Domain IPR027370 Zinc finger, RING-type, eukaryotic
Family IPR038896 E3 ubiquitin-protein ligase RNF170
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Domain Details Per Protein
Protein Length Domain of unknown function DUF1232 E3 ubiquitin-protein ligase RNF170 Zinc finger, RING/FYVE/PHD-type Zinc finger, RING-type Zinc finger, RING-type, conserved site Zinc finger, RING-type, eukaryotic
UniProtKB:Q7SZN2 266
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations