ZFIN ID: ZDB-GENE-040426-2493
Gene Name: methylcrotonoyl-CoA carboxylase 2 (beta)
Gene Symbol: mccc2    Nomenclature History

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Previous Names: si:dkey-57m14.1 (1), zgc:85685

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to contribute to methylcrotonoyl-CoA carboxylase activity. Predicted to be involved in leucine catabolic process. Predicted to localize to methylcrotonoyl-CoA carboxylase complex and mitochondrion. Human ortholog(s) of this gene implicated in 3-Methylcrotonyl-CoA carboxylase 2 deficiency and mitochondrial metabolism disease. Orthologous to human MCCC2 (methylcrotonoyl-CoA carboxylase 2).
Genome Resources: Alliance (1),  Gene:405863 (1),  Ensembl(GRCz11):ENSDARG00000017571 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:85685]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH mccc2 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
3-Methylcrotonyl-CoA carboxylase 2 deficiency Alliance 3-Methylcrotonyl-CoA carboxylase 2 deficiency 210210
DISEASE ASSOCIATED WITH mccc2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process leucine catabolic process (more)
Cellular Component methylcrotonoyl-CoA carboxylase complex (more)
Molecular Function ligase activity (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA mccc2-201 (1)    Ensembl 2037
ncRNA mccc2-002 (1)    Ensembl 290
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM mccc2 No data available
MARKER RELATIONSHIPS
mccc2 Contained in: [BAC] DKEY-57M14 (1) (order this)
mccc2 Encodes: [cDNA] MGC:85685 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_212927 (1) 1896 nt
Genomic GenBank:BX950211 (1) 134143 nt
Select Tool
Polypeptide UniProtKB:A2BIN5 (1) 566 aa
Sequence Information (all 9)
ORTHOLOGY for mccc2 ( Chr: 5 )
CITATIONS (19)