Gene

mccc2

ID
ZDB-GENE-040426-2493
Name
methylcrotonyl-CoA carboxylase subunit 2
Symbol
mccc2 Nomenclature History
Previous Names
  • si:dkey-57m14.1 (1)
  • zgc:85685
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to contribute to methylcrotonoyl-CoA carboxylase activity. Predicted to be involved in leucine catabolic process. Predicted to localize to methylcrotonoyl-CoA carboxylase complex and mitochondrion. Human ortholog(s) of this gene implicated in 3-Methylcrotonyl-CoA carboxylase 2 deficiency and mitochondrial metabolism disease. Orthologous to human MCCC2 (methylcrotonoyl-CoA carboxylase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mccc2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
3-methylcrotonyl-CoA carboxylase 2 deficiency Alliance 3-Methylcrotonyl-CoA carboxylase 2 deficiency 210210
Associated With mccc2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011762 Acetyl-coenzyme A carboxyltransferase, N-terminal
Domain IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminal
Domain IPR034733 Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
Family IPR045190 Methylcrotonoyl-CoA carboxylase beta chain MCCB/AccD1-like
Homologous_superfamily IPR029045 ClpP/crotonase-like domain superfamily
Domain Details Per Protein
Protein Length Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta Acetyl-coenzyme A carboxyltransferase, C-terminal Acetyl-coenzyme A carboxyltransferase, N-terminal ClpP/crotonase-like domain superfamily Methylcrotonoyl-CoA carboxylase beta chain MCCB/AccD1-like
UniProtKB:Q6NWI5 566
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations