ZFIN ID: ZDB-GENE-040426-2459
Gene Name: dihydropyrimidine dehydrogenase b
Gene Symbol: dpydb    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: dpyd, zgc:77205 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have several functions, including NADP binding activity; dihydropyrimidine dehydrogenase (NADP+) activity; and uracil binding activity. Predicted to be involved in thymidine catabolic process; thymine catabolic process; and uracil catabolic process. Predicted to localize to cytosol. Is expressed in intestinal bulb; liver; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and pancreatic cancer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase).
Genome Resources: Alliance (1),  Gene:405829 (1),  Ensembl(GRCz11):ENSDARG00000010267 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 7 figures (9 images) from Thisse et al., 2004 [MGC:77205]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a330 Small Deletion Unknown Unknown
sa17210 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-dpydb 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH dpydb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    dihydropyrimidine dehydrogenase deficiency Alliance 5-fluorouracil toxicity 274270
    Dihydropyrimidine dehydrogenase deficiency 274270
    DISEASE ASSOCIATED WITH dpydb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process thymidine catabolic process (more)
    Cellular Component cytoplasm (more)
    Molecular Function dihydropyrimidine dehydrogenase (NADP+) activity (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dpydb-201 (1)    Ensembl 3275
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dpydb No data available
    MARKER RELATIONSHIPS
    dpydb Contained in: [BAC] CH73-331C10 (1), CH211-160L17 (1), CH211-254O14 (1)
    dpydb Encodes: [cDNA] MGC:77205 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212893 (1) 3593 nt
    Genomic GenBank:BX005269 (1) 185170 nt
    Select Tool
    Polypeptide UniProtKB:F1QUE6 (1) 1022 aa
    Sequence Information (all 24)
    ORTHOLOGY for dpydb ( Chr: 2 )
    CITATIONS (27)