Gene

dpydb

ID
ZDB-GENE-040426-2459
Name
dihydropyrimidine dehydrogenase b
Symbol
dpydb Nomenclature History
Previous Names
  • dpyd
  • zgc:77205 (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have several functions, including NADP binding activity; dihydropyrimidine dehydrogenase (NADP+) activity; and uracil binding activity. Predicted to be involved in thymidine catabolic process; thymine catabolic process; and uracil catabolic process. Predicted to localize to cytosol. Is expressed in intestinal bulb; liver; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and pancreatic cancer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dpydb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
dihydropyrimidine dehydrogenase deficiency Alliance 5-fluorouracil toxicity 274270
dihydropyrimidine dehydrogenase deficiency Alliance Dihydropyrimidine dehydrogenase deficiency 274270
Associated With dpydb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
Domain IPR005720 Dihydroorotate dehydrogenase domain
Domain IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain
Domain IPR023753 FAD/NAD(P)-binding domain
Domain IPR028261 Dihydroprymidine dehydrogenase domain II
Homologous_superfamily IPR009051 Alpha-helical ferredoxin
Homologous_superfamily IPR013785 Aldolase-type TIM barrel
Homologous_superfamily IPR036188 FAD/NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length 4Fe-4S ferredoxin, iron-sulphur binding, conserved site 4Fe-4S ferredoxin-type, iron-sulphur binding domain Aldolase-type TIM barrel Alpha-helical ferredoxin Dihydroorotate dehydrogenase domain Dihydroprymidine dehydrogenase domain II FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain superfamily
UniProtKB:F1QUE6 1022
UniProtKB:A0A2R8QU12 985
UniProtKB:Q6NYG8 1022
UniProtKB:F1QX36 945
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations