Gene

dpydb

ID
ZDB-GENE-040426-2459
Name
dihydropyrimidine dehydrogenase b
Symbol
dpydb Nomenclature History
Previous Names
  • dpyd
  • zgc:77205 (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have several functions, including NADP binding activity; dihydropyrimidine dehydrogenase (NADP+) activity; and uracil binding activity. Predicted to be involved in thymidine catabolic process; thymine catabolic process; and uracil catabolic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and pancreatic cancer. Is expressed in intestinal bulb; liver; pronephric duct; and yolk syncytial layer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dpydb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
5-fluorouracil toxicity 274270
Dihydropyrimidine dehydrogenase deficiency 274270
Associated With dpydb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
Domain IPR005720 Dihydroorotate dehydrogenase, catalytic
Domain IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain
Domain IPR023753 FAD/NAD(P)-binding domain
Domain IPR028261 Dihydroprymidine dehydrogenase domain II
Homologous_superfamily IPR009051 Alpha-helical ferredoxin
Homologous_superfamily IPR013785 Aldolase-type TIM barrel
Homologous_superfamily IPR036188 FAD/NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length 4Fe-4S ferredoxin, iron-sulphur binding, conserved site 4Fe-4S ferredoxin-type, iron-sulphur binding domain Aldolase-type TIM barrel Alpha-helical ferredoxin Dihydroorotate dehydrogenase, catalytic Dihydroprymidine dehydrogenase domain II FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain superfamily
UniProtKB:Q6NYG8 1022
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA dpydb-201 (1) Havana 3275 nt
mRNA dpydb-202 (1) Ensembl 5381 nt
mRNA dpydb-203 (1) Ensembl 5270 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations