ZFIN ID: ZDB-GENE-040426-2434
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Gene Name: microspherule protein 1
Gene Symbol: mcrs1    Nomenclature History

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Previous Names: wu:fj97a11, zgc:66428 (1), zgc:77376 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to contribute to histone acetyltransferase activity (H4-K16 specific); histone acetyltransferase activity (H4-K5 specific); and histone acetyltransferase activity (H4-K8 specific). Involved in cilium assembly and retina layer formation. Predicted to localize to the NSL complex. Is expressed in brain; eye; pronephros; and spinal cord. Orthologous to human MCRS1 (microspherule protein 1).
Genome Resources: Alliance (1),  Gene:406557 (1),  Ensembl(GRCz11):ENSDARG00000020840 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7137984]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ck018 Small Deletion Exon 4 Unknown TALEN
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
TALEN1-mcrs1 1
PHENOTYPE
Data: 2 figures from Lee et al., 2016
Observed in:
DISEASE ASSOCIATED WITH mcrs1 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH mcrs1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cilium assembly (more)
Cellular Component Ino80 complex (more)
Molecular Function G-quadruplex RNA binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR000253 Forkhead-associated (FHA) domain
Homologous_superfamily IPR008984 SMAD/FHA domain superfamily
Domain IPR025999 Microspherule protein, N-terminal domain
Family IPR037912 Microspherule protein 1
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA mcrs1-201 (1)    Ensembl 2289
Select Tool
ncRNA mcrs1-002 (1)    Ensembl 295
Select Tool
Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM mcrs1 No data available
MARKER RELATIONSHIPS
mcrs1 Contained in: [Fosmid] ZFOS-1468H2 (1)
mcrs1 Encodes: [EST] fj97a11 (1), IMAGE:7137984 (1)
[cDNA] MGC:66428 (1), MGC:77376 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_213273 (1) 2265 bp
Select Tool
Genomic GenBank:CU694494 (1) 29343 bp
Select Tool
Polypeptide UniProtKB:Q6P0E3 (1) 472 aa
Select Tool
Sequence Information (all 17)
ORTHOLOGY for mcrs1 ( Chr: 11 )
CITATIONS (19)