ZFIN ID: ZDB-GENE-040426-2371
Gene Name: dynamin 2b
Gene Symbol: dnm2b    Nomenclature History

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Previous Names: dnm2l, zgc:77233

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have GTP binding activity and GTPase activity. Involved in several processes, including glomerular filtration; glomerular visceral epithelial cell development; and muscle fiber development. Predicted to localize to microtubule. Is expressed in brain; heart; liver; muscle; and spinal cord. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; and lethal congenital contracture syndrome. Orthologous to human DNM2 (dynamin 2).
Genome Resources: Alliance (1),  Gene:406525 (1),  Ensembl(GRCz11):ENSDARG00000103054 (1)
GENE EXPRESSION
All Expression Data: Fig. 2 from Gibbs et al., 2013
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa19634 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38304 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dnm2b N/A 2
    DISEASE ASSOCIATED WITH dnm2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    centronuclear myopathy 1 Alliance Centronuclear myopathy 1 160150
    Charcot-Marie-Tooth disease dominant intermediate B Alliance Charcot-Marie-Tooth disease, axonal type 2M 606482
    Charcot-Marie-Tooth disease, dominant intermediate B 606482
    Lethal congenital contracture syndrome 5 615368
    DISEASE ASSOCIATED WITH dnm2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chordate embryonic development (more)
    Cellular Component microtubule (more)
    Molecular Function GTPase activity (more)
    GO Terms (all 32)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM dnm2b No data available
    MARKER RELATIONSHIPS
    dnm2b Encodes: [cDNA] MGC:77233 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213242 (1) 3681 nt
    Genomic GenBank:CABZ01084497 (1) 3908 nt
    Polypeptide UniProtKB:Q6P122 (1) 856 aa
    Sequence Information (all 17)
    ORTHOLOGY for dnm2b ( Chr: 1 )
    CITATIONS (18)