Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-040426-2338
Gene Name: sprouty-related, EVH1 domain containing 1
Gene Symbol: spred1
Previous Names: fb14c08, fj51c03, wu:fb14c08 (1), wu:fj51c03 (1), zgc:85707 (1)
Location: Chr: 17   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:85707]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
  unspecified
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: sa15659
Knockdown reagents: MO1-spred1 (1), MO2-spred1 (1), MO3-spred1 (1)
PHENOTYPE
Data: Fig. S9 from Fish et al., 2008
Observed in: blood circulation, cranial vasculature, heart

Phenotype of Human Orthologue OMIM Phenotype ID
Legius syndrome 611431
GENE ONTOLOGY
Ontology GO Term
Biological Process blood vessel morphogenesis (more)
Cellular Component membrane (more)
Molecular Function molecular_function (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000697 (1)
  • InterPro:IPR007875 (1)
  • InterPro:IPR011993 (1)
  • InterPro:IPR023337 (1)
  • PROSITE:PS50229 (1)
  • PROSITE:PS51227 (1)
  • PROSITE:PS51488 (1)
  • Pfam:PF00568 (1)
  • Pfam:PF05210 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA spred1-001 (1) 3432
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM spred1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    spred1 Contained in: [BAC] CH73-275L12 (1) (order this), CH211-173A9 (1) (order this)
    spred1 Encodes: [EST] fb14c08, fj51c03
    [cDNA] MGC:85707 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213232 (1) 3089 bp
    Genomic GenBank:AL935141 (1) 136178 bp
    Select Tool
    Polypeptide UniProtKB:F1R8L9 (1) 391 aa
    Sequence Clusters UniGene:76703 (1)
    Sequence Information (all 14)
    OTHER spred1 GENE PAGES
  • Gene:406513 (1)
  • VEGA:OTTDARG00000035030 (1)
  • Ensembl(Zv9):ENSDARG00000041449 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish spred1 17  
    Human SPRED1 15 (15q14)
  • OMIM:609291
  • Gene:161742
  • Mouse Spred1 2 ( 59.03 cM)
  • MGI:2150016
  • Gene:114715
  • Orthology Details
    CITATIONS (17)