ZFIN ID: ZDB-GENE-040426-2338
Gene Name: sprouty related EVH1 domain containing 1
Gene Symbol: spred1    Nomenclature History

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Previous Names: fb14c08, fj51c03, wu:fb14c08 (1), wu:fj51c03 (1), zgc:85707 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have protein kinase binding activity. Involved in blood vessel morphogenesis; lymph vessel development; and regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to localize to membrane. Orthologous to human SPRED1 (sprouty related EVH1 domain containing 1).
Genome Resources: Alliance (1),  Gene:406513 (1),  Ensembl(GRCz11):ENSDARG00000041449 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:85707]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6494 Point Mutation Unknown Premature Stop ENU
sa15659 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32178 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-spred1
    1
    MO1-spred1 N/A 1
    MO2-spred1 N/A 1
    MO3-spred1 N/A 1
    MO4-spred1 N/A 1
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH spred1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Legius syndrome 611431
    DISEASE ASSOCIATED WITH spred1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process lymph vessel development (more)
    Cellular Component membrane (more)
    Molecular Function protein kinase binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA spred1-201 (1)    Ensembl 3432
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM spred1 No data available
    MARKER RELATIONSHIPS
    spred1 Contained in: [BAC] CH73-275L12 (1), CH211-173A9 (1)
    spred1 Encodes: [EST] fb14c08, fj51c03
    [cDNA] MGC:85707 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213232 (1) 3089 nt
    Genomic GenBank:AL935141 (1) 136178 nt
    Select Tool
    Polypeptide UniProtKB:F1R8L9 (1) 391 aa
    Sequence Information (all 17)
    ORTHOLOGY for spred1 ( Chr: 17 )
    CITATIONS (25)