ZFIN ID: ZDB-GENE-040426-2315
Gene Name: MARCKS-like 1b
Gene Symbol: marcksl1b    Nomenclature History

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Previous Names: marcksl1a (1), wu:fa11h06, zgc:85717

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have calmodulin binding activity. Involved in cartilage development; central nervous system development; and neural retina development. Predicted to localize to cytoplasm; cytoskeleton; and plasma membrane. Is expressed in brain; eye; and skeletal muscle. Orthologous to human MARCKSL1 (MARCKS like 1).
Genome Resources: Alliance (1),  Gene:406504 (1),  Ensembl(GRCz11):ENSDARG00000035715 (2)
Note: Prieto and Zolessi (2017) suggest that the "a" and "b" designations, established in 2012, of the marcksl1 paralogs, should be reversed based on structural and functional similarities to the MARCKSL1 genes. No changes were made because the "a" and "b" designations are not reflective of priority in discovery, function or structure but are designated based on the evidence available at the time of the nomenclature event for the evolutionary and syntenic relationship to the ancestral gene.
GENE EXPRESSION
All Expression Data: Fig. 2 from Prieto et al., 2017
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-marcksl1b
1
MO1-marcksl1b N/A 1
MO2-marcksl1b N/A 1
DISEASE ASSOCIATED WITH marcksl1b HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH marcksl1b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cartilage development (more)
Cellular Component cytoplasm (more)
Molecular Function calmodulin binding (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA marcksl1b-201 (1)    Ensembl 1558
marcksl1b-202 (1)    Ensembl 923
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM marcksl1b No data available
MARKER RELATIONSHIPS
marcksl1b Contained in: [BAC] CH73-196C24 (1)
marcksl1b Encodes: [EST] fa11h06 (1)
[STS] chunp30008
[cDNA] MGC:85717 (1), MGC:174415 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_213223 (1) 1696 nt
Genomic GenBank:CU861666 (1) 93406 nt
Select Tool
Polypeptide UniProtKB:Q6NWH2 (1) 207 aa
Sequence Information (all 19)
ORTHOLOGY for marcksl1b ( Chr: 19 )
CITATIONS (26)