ZFIN ID: ZDB-GENE-040426-2252
Gene Name: tumor necrosis factor receptor superfamily, member 1a
Gene Symbol: tnfrsf1a    Nomenclature History

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Previous Names: TNFR1 (1), TNF Receptor 1 (TR1) (1), wu:fj65b10, zgc:85914

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have tumor necrosis factor binding activity and tumor necrosis factor-activated receptor activity. Involved in several processes, including defense response to other organism; fin regeneration; and neutrophil chemotaxis. Predicted to localize to membrane raft; mitochondrion; and receptor complex. Is expressed in several structures, including heart; nervous system; notochord; otic vesicle; and pronephric duct. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; Legionnaires' disease; acne; allergic bronchopulmonary aspergillosis; and autosomal dominant familial periodic fever. Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A).
Genome Resources: Alliance (1),  Gene:406471 (1),  Ensembl(GRCz11):ENSDARG00000018569 (2)
GENE EXPRESSION
All Expression Data: 11 figures from 7 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:85914]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb319 Insertion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • ihb320 Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • sa8496 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15813 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tnfrsf1a 1
    CRISPR2-tnfrsf1a
    1
    MO1-tnfrsf1a N/A 5
    MO2-tnfrsf1a N/A 13
    MO3-tnfrsf1a N/A 2
    PHENOTYPE
    Data: Fig. 3 from Troll et al., 2018
    Observed in:
    DISEASE ASSOCIATED WITH tnfrsf1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant familial periodic fever Alliance Periodic fever, familial 142680
    {Multiple sclerosis, susceptibility to, 5} 614810
    DISEASE ASSOCIATED WITH tnfrsf1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of granuloma formation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function tumor necrosis factor-activated receptor activity (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tnfrsf1a-201 (1)    Ensembl 2509
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tnfrsf1a No data available
    MARKER RELATIONSHIPS
    tnfrsf1a Contained in: [BAC] CH211-215M13 (1)
    tnfrsf1a Encodes: [EST] fj65b10
    [cDNA] MGC:85914 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213190 (1) 2543 nt
    Genomic GenBank:CR533575 (1) 115032 nt
    Select Tool
    Polypeptide UniProtKB:F1QQS0 (1) 389 aa
    Sequence Information (all 10)
    ORTHOLOGY for tnfrsf1a ( Chr: 16 )
    CITATIONS (51)