Gene

tnfrsf1a

ID
ZDB-GENE-040426-2252
Name
tumor necrosis factor receptor superfamily, member 1a
Symbol
tnfrsf1a Nomenclature History
Previous Names
  • TNFR1 (1)
  • TNF Receptor 1 (TR1) (1)
  • wu:fj65b10
  • zgc:85914
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to enable tumor necrosis factor binding activity and tumor necrosis factor-activated receptor activity. Acts upstream of or within several processes, including defense response to other organism; fin regeneration; and neutrophil chemotaxis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in membrane raft and mitochondrion. Is expressed in several structures, including heart; nervous system; notochord; otic vesicle; and pronephric duct. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Troll et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tnfrsf1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant familial periodic fever Alliance Periodic fever, familial 142680
{Multiple sclerosis, susceptibility to, 5} 614810
Associated With tnfrsf1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000488 Death domain
Domain IPR001368 TNFR/NGFR cysteine-rich region
Domain IPR033994 Tumor necrosis factor receptor 1A, death domain
Domain IPR033995 Tumor necrosis factor receptor superfamily member 1A, N-terminal, teleost
Homologous_superfamily IPR011029 Death-like domain superfamily
Domain Details Per Protein
Protein Length Death domain Death-like domain superfamily TNFR/NGFR cysteine-rich region Tumor necrosis factor receptor 1A, death domain Tumor necrosis factor receptor superfamily member 1A, N-terminal, teleost
UniProtKB:Q6NUU6 389
UniProtKB:F1QQS0 389
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations