Gene

pla2g7

ID
ZDB-GENE-040426-2248
Name
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Symbol
pla2g7 Nomenclature History
Previous Names
  • zgc:77563 (1)
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have 1-alkyl-2-acetylglycerophosphocholine esterase activity. Predicted to be involved in lipid catabolic process. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); glomerulonephritis (multiple); hemolytic-uremic syndrome; proteinuria (multiple); and type 2 diabetes mellitus. Is expressed in lens and solid lens vesicle. Orthologous to several human genes including PLA2G7 (phospholipase A2 group VII).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pla2g7 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
asthma Alliance {Asthma, susceptibility to} 600807
Platelet-activating factor acetylhydrolase deficiency 614278
{Atopy, susceptibility to} 147050
Associated With pla2g7 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR005065 Platelet-activating factor acetylhydrolase-like
Family IPR016715 Platelet-activating factor acetylhydrolase, eucaryote
Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
Domain Details Per Protein
Protein Length Alpha/Beta hydrolase fold Platelet-activating factor acetylhydrolase, eucaryote Platelet-activating factor acetylhydrolase-like
UniProtKB:U3JAC2 214
UniProtKB:Q5RHM0 444
UniProtKB:Q6NYI7 404
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations