Gene

nfkbiaa

ID
ZDB-GENE-040426-2227
Name
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a
Symbol
nfkbiaa Nomenclature History
Previous Names
  • ikbaa (1)
  • fj16a07
  • wu:fj16a07
  • zgc:85769 (1)
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Involved in negative regulation of hematopoietic progenitor cell differentiation and response to virus. Is expressed in several structures, including lateral line system; periderm; pronephric duct; tail bud; and vent. Human ortholog(s) of this gene implicated in hematologic cancer (multiple); hypohidrotic ectodermal dysplasia; lung cancer; melanoma; and prostate cancer. Orthologous to human NFKBIA (NFKB inhibitor alpha).
Genome Resources
Note
None
Expression
All Expression Data
16 figures from 10 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from He et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nfkbiaa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Ectodermal dysplasia and immunodeficiency 2 612132
Associated With nfkbiaa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR020683 Ankyrin repeat-containing domain
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat-containing domain Ankyrin repeat-containing domain superfamily
UniProtKB:Q6K196 312
UniProtKB:Q6NUY5 305
UniProtKB:F1QCG4 310
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations