ZFIN ID: ZDB-GENE-040426-2227
Gene Name: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a
Gene Symbol: nfkbiaa    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: ikbaa (1), fj16a07, wu:fj16a07, zgc:85769 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Involved in negative regulation of hematopoietic progenitor cell differentiation and response to virus. Human ortholog(s) of this gene implicated in hematologic cancer (multiple); hypohidrotic ectodermal dysplasia; lung cancer; melanoma; and prostate cancer. Is expressed in several structures, including lateral line system; periderm; pronephric duct; tail bud; and vent. Orthologous to human NFKBIA (NFKB inhibitor alpha).
Genome Resources: Alliance (1),  Gene:406463 (1),  Ensembl(GRCz11):ENSDARG00000005481 (2)
GENE EXPRESSION
All Expression Data: 12 figures from 7 publications
Directly Submitted Expression Data: 6 figures (13 images) from Thisse et al., 2004 [MGC:85769]
Wild-type Stages, Structures: Cleavage:32-cell (1.75h-2.0h) to Larval:Day 4 (96.0h-120.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-nfkbiaa N/A 2
DISEASE ASSOCIATED WITH nfkbiaa HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Ectodermal dysplasia and immunodeficiency 2 612132
DISEASE ASSOCIATED WITH nfkbiaa VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process response to virus (more)
GO Terms (all 3)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Repeat IPR002110 Ankyrin repeat
Domain IPR020683 Ankyrin repeat-containing domain
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA nfkbiaa-202 (1)    Ensembl 1344
ncRNA nfkbiaa-002 (1)    Ensembl 864
nfkbiaa-003 (1)    Ensembl 838
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM nfkbiaa
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(4xUAS:dnnfkbiaa) UAS nfkbiaa Danio rerio 0 1
Tg(4xUAS:dnnfkbiaa,myl7:GFP) myl7UAS GFPnfkbiaa Danio rerio 1 2
MARKER RELATIONSHIPS
nfkbiaa Contained in: [BAC] CH73-77M20 (1)
nfkbiaa Encodes: [EST] fj16a07
[cDNA] MGC:85769 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_213184 (1) 1322 bp
Genomic GenBank:CU855900 (1) 77859 bp
Select Tool
Polypeptide UniProtKB:Q6K196 (1) 312 aa
Sequence Information (all 16)
ORTHOLOGY for nfkbiaa ( Chr: 20 )
CITATIONS (58)