Gene

orc4

ID
ZDB-GENE-040426-2224
Name
origin recognition complex, subunit 4
Symbol
orc4 Nomenclature History
Previous Names
  • fc50c03
  • wu:fc50c03
  • zgc:85772
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to enable DNA replication origin binding activity. Acts upstream of or within cilium assembly. Predicted to be located in nucleus. Predicted to be part of nuclear origin of replication recognition complex. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 2. Orthologous to human ORC4 (origin recognition complex subunit 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Idilli et al., 2020
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Maerz et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With orc4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Meier-Gorlin syndrome 2 Alliance Meier-Gorlin syndrome 2 613800
Associated With orc4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003593 AAA+ ATPase domain
Domain IPR032705 Origin recognition complex subunit 4, C-terminal
Domain IPR041664 Orc1-like, AAA ATPase domain
Family IPR016527 Origin recognition complex subunit 4
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length AAA+ ATPase domain Orc1-like, AAA ATPase domain Origin recognition complex subunit 4 Origin recognition complex subunit 4, C-terminal P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q6NWF3 432
UniProtKB:F1QRE0 432
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations