Gene
epcam
- ID
- ZDB-GENE-040426-2209
- Name
- epithelial cell adhesion molecule
- Symbol
- epcam Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Involved in several processes, including epiboly involved in gastrulation with mouth forming second; liver development; and posterior lateral line neuromast primordium migration. Localizes to basolateral plasma membrane and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in congenital diarrhea 5 with tufting enteropathy and hereditary nonpolyposis colorectal cancer type 8. Is expressed in several structures, including digestive system; integument; pectoral fin bud; pronephros; and sensory system. Orthologous to human EPCAM (epithelial cell adhesion molecule).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb6 (24 images)
Wild Type Expression Summary
- All Phenotype Data
- 20 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital diarrhea 5 with tufting enteropathy | Alliance | Diarrhea 5, with tufting enteropathy, congenital | 613217 |
| hereditary nonpolyposis colorectal cancer type 8 | Alliance | Lynch syndrome 8 | 613244 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | EPCAM/Trop-2, C-terminal | Thyroglobulin type-1 | Thyroglobulin type-1 superfamily | Transmembrane glycoprotein EPCAM/Trop-2 |
|---|---|---|---|---|---|
|
UniProtKB:Q568H0
|
303 |
Interactions and Pathways
No data available
Plasmids
No data available