ZFIN ID: ZDB-GENE-040426-2185
Gene Name: tropomyosin 4a
Gene Symbol: tpm4a    Nomenclature History

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Previous Names: TPM4-1 (1), tpm4, wu:fb06e07, zgc:103436, zgc:63909

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity. Involved in cardiac muscle contraction and cardiac myofibril assembly. Predicted to localize to actin filament. Is expressed in several structures, including cardiovascular system; head mesenchyme; mesoderm; muscle; and thymus. Orthologous to human TPM4 (tropomyosin 4).
Genome Resources: Alliance (1),  Gene:406437 (1),  Ensembl(GRCz11):ENSDARG00000023963 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ct31aGt Transgenic Insertion Unknown Unknown DNA
sa11492 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zf152Gt Transgenic Insertion Unknown Unknown DNA
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tpm4a N/A 1
    MO2-tpm4a N/A 1
    MO3-tpm4a N/A 1
    MO4-tpm4a N/A 1
    MO5-tpm4a N/A 2
    DISEASE ASSOCIATED WITH tpm4a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH tpm4a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cardiac muscle contraction (more)
    Cellular Component actin filament (more)
    Molecular Function actin filament binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tpm4a-204 (1)    Ensembl 743
    tpm4a-205 (1)    Ensembl 1261
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tpm4a No data available
    MARKER RELATIONSHIPS
    tpm4a Contained in: [BAC] RP71-69P9 (1)
    tpm4a Encodes: [EST] fb06e07 (1)
    [cDNA] MGC:63909 (1), MGC:103436 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213158 (1) 1804 nt
    Genomic GenBank:BX322595 (1) 147460 nt
    Select Tool
    Polypeptide UniProtKB:F1QKG7 (1) 284 aa
    Sequence Information (all 29)
    ORTHOLOGY for tpm4a ( Chr: 22 )
    CITATIONS (41)