ZFIN ID: ZDB-GENE-040426-2157
Gene Name: OTU deubiquitinase with linear linkage specificity a
Gene Symbol: otulina    Nomenclature History

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Previous Names: fam105ba, wu:fj43e01, zgc:64095

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have thiol-dependent ubiquitin-specific protease activity. Predicted to be involved in protein linear deubiquitination. Predicted to colocalize with LUBAC complex. Is expressed in alar plate midbrain region; lens; optic tectum; retina; and solid lens vesicle. Human ortholog(s) of this gene implicated in otulipenia. Orthologous to several human genes including YAE1 (YAE1 maturation factor of ABCE1).
Genome Resources: Alliance (1),  Gene:406416 (1),  Ensembl(GRCz11):ENSDARG00000045422 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 4 figures (4 images) from Thisse et al., 2004 [MGC:64095]
  4 figures (5 images) from Thisse et al., 2004 [IMAGE:6909406]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la022831Tg Transgenic Insertion Unknown Unknown DNA
sa7513 Point Mutation Unknown Missense ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-otulina
1
CRISPR2-otulina
1
CRISPR3-otulina
1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH otulina HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
otulipenia Alliance Autoinflammation, panniculitis, and dermatosis syndrome 617099
DISEASE ASSOCIATED WITH otulina VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process protein linear deubiquitination (more)
Cellular Component cytoplasm (more)
Molecular Function thiol-dependent ubiquitin-specific protease activity (more)
GO Terms (all 4)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
aberrant processed transcript otulina-205 (1)    Ensembl 931
mRNA otulina-201 (1)    Ensembl 1268
otulina-202 (1)    Ensembl 535
otulina-204 (1)    Ensembl 3081
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM otulina No data available
MARKER RELATIONSHIPS
otulina Contained in: [BAC] CH211-124O16 (1)
otulina Encodes: [EST] fj43e01, IMAGE:6909406 (1)
[cDNA] MGC:64095 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_213142 (1) 1267 nt
Genomic GenBank:CR391965 (1) 183705 nt
Select Tool
Polypeptide UniProtKB:F1QGG2 (1) 858 aa
Sequence Information (all 16)
ORTHOLOGY for otulina ( Chr: 24 )
CITATIONS (23)