ZFIN ID: ZDB-GENE-040426-2148
Gene Name: cytochrome b5 type A (microsomal)
Gene Symbol: cyb5a    Nomenclature History

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Previous Names: wu:fb44a11, zgc:64123

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Exhibits heme binding activity. Involved in cellular response to xenobiotic stimulus and oxidation-reduction process. Predicted to localize to intracellular membrane-bounded organelle and membrane. Is expressed in digestive system; head; immature eye; neural crest; and optic stalk. Human ortholog(s) of this gene implicated in methemoglobinemia. Orthologous to human CYB5A (cytochrome b5 type A).
Genome Resources: Alliance (1),  Gene:406409 (1),  Ensembl(GRCz11):ENSDARG00000098589 (1)
GENE EXPRESSION
All Expression Data: 9 figures from 3 publications
Directly Submitted Expression Data: 5 figures (7 images) from Thisse et al., 2004 [MGC:64123]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH cyb5a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Methemoglobinemia and ambiguous genitalia 250790
DISEASE ASSOCIATED WITH cyb5a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cellular response to xenobiotic stimulus (more)
Cellular Component integral component of membrane (more)
Molecular Function heme binding (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA cyb5a-201 (1)    Ensembl 1517
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM cyb5a No data available
MARKER RELATIONSHIPS
cyb5a Contained in: [BAC] CH211-152C8 (1)
cyb5a Encodes: [EST] fb44a11
[cDNA] MGC:64123 (1), MGC:175075 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_213135 (1) 1376 nt
Genomic GenBank:BX784022 (1) 153244 nt
Select Tool
Polypeptide UniProtKB:A8WGS0 (1) 137 aa
Sequence Information (all 17)
ORTHOLOGY for cyb5a ( Chr: 24 )
CITATIONS (25)