ZFIN ID: ZDB-GENE-040426-2147
Gene Name: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
Gene Symbol: ddost    Nomenclature History

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Previous Names: wu:fa11d01, zgc:66068, zgc:77478

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to contribute to dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Predicted to be involved in protein N-linked glycosylation via asparagine. Predicted to localize to the oligosaccharyltransferase complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ir. Is expressed in axis; notochord; and polster. Orthologous to human DDOST (dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit).
Genome Resources: Alliance (1),  Gene:406408 (1),  Ensembl(GRCz11):ENSDARG00000037318 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (9 images) from Thisse et al., 2004 [IMAGE:6905658]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7161736]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9278 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37698 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ddost HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital disorder of glycosylation Ir Alliance ?Congenital disorder of glycosylation, type Ir 614507
    DISEASE ASSOCIATED WITH ddost VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein N-linked glycosylation via asparagine (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function CONTRIBUTES_TO   dolichyl-diphosphooligosaccharide-protein glycotransferase activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR005013 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kDa subunit
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ddost-201 (1)    Ensembl 1884
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ddost No data available
    MARKER RELATIONSHIPS
    ddost Contained in: [BAC] DKEY-21O19 (1) (order this)
    ddost Encodes: [EST] fa11d01 (1), IMAGE:6905658 (1), IMAGE:7161736 (1)
    [cDNA] MGC:66068 (1), MGC:77478 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213093 (1) 1845 nt
    Genomic GenBank:CR925709 (1) 151006 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4I9F5 (1) 441 aa
    Sequence Information (all 16)
    ORTHOLOGY for ddost ( Chr: 23 )
    CITATIONS (28)