Gene

mdh2

ID
ZDB-GENE-040426-2143
Name
malate dehydrogenase 2, NAD (mitochondrial)
Symbol
mdh2 Nomenclature History
Previous Names
  • wu:fj48c08
  • wu:fj55d06
  • zgc:64133
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to enable L-malate dehydrogenase activity. Predicted to be involved in tricarboxylic acid cycle. Predicted to act upstream of or within carbohydrate metabolic process and malate metabolic process. Predicted to be active in mitochondrion. Is expressed in alar plate midbrain region; brain; eye; immature eye; and musculature system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mdh2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
developmental and epileptic encephalopathy 51 Alliance Developmental and epileptic encephalopathy 51 617339
Associated With mdh2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR001252 Malate dehydrogenase, active site
Domain IPR001236 Lactate/malate dehydrogenase, N-terminal
Domain IPR022383 Lactate/malate dehydrogenase, C-terminal
Family IPR001557 L-lactate/malate dehydrogenase
Family IPR010097 Malate dehydrogenase, type 1
Homologous_superfamily IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal Lactate/malate dehydrogenase, C-terminal Lactate/malate dehydrogenase, N-terminal L-lactate/malate dehydrogenase Malate dehydrogenase, active site Malate dehydrogenase, type 1 NAD(P)-binding domain superfamily
UniProtKB:Q7T334 337
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations