ZFIN ID: ZDB-GENE-040426-2143
Gene Name: malate dehydrogenase 2, NAD (mitochondrial)
Gene Symbol: mdh2    Nomenclature History

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Previous Names: wu:fj48c08, wu:fj55d06, zgc:64133

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have L-malate dehydrogenase activity. Predicted to be involved in tricarboxylic acid cycle. Predicted to localize to mitochondrion. Is expressed in alar plate midbrain region; brain; eye; immature eye; and musculature system. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2).
Genome Resources: Alliance (1),  Gene:406405 (1),  Ensembl(GRCz11):ENSDARG00000043371 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 4 publications
Directly Submitted Expression Data: 5 figures (4 images) from Thisse et al., 2004 [MGC:64133]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH mdh2 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
early infantile epileptic encephalopathy 51 Alliance Epileptic encephalopathy, early infantile, 51 617339
DISEASE ASSOCIATED WITH mdh2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process carbohydrate metabolic process (more)
Cellular Component cytoplasm (more)
Molecular Function catalytic activity (more)
GO Terms (all 12)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM mdh2 No data available
MARKER RELATIONSHIPS
mdh2 Encodes: [EST] fj48c08 (1), fj55d06 (1)
[cDNA] MGC:64133 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_213131 (1)
Polypeptide UniProtKB:Q7T334 (1) 337 aa
Sequence Information (all 12)
ORTHOLOGY for mdh2 ( Chr: 10 )
CITATIONS (26)