ZFIN ID: ZDB-GENE-040426-2058
Gene Name: 2-hydroxyacyl-CoA lyase 1
Gene Symbol: hacl1    Nomenclature History

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Previous Names: phyh2 (1), wu:fd42e11, zgc:76920 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have carbon-carbon lyase activity and thiamine pyrophosphate binding activity. Predicted to be involved in fatty acid alpha-oxidation. Predicted to localize to peroxisome. Orthologous to human HACL1 (2-hydroxyacyl-CoA lyase 1).
Genome Resources: Alliance (1),  Gene:406358 (1),  Ensembl(GRCz11):ENSDARG00000020529 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa5889 Point Mutation Unknown Splice Site ENU
sa39097 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-hacl1 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hacl1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hacl1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process fatty acid alpha-oxidation (more)
    Cellular Component peroxisome (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript hacl1-202 (1)    Ensembl 473
    mRNA hacl1-201 (1)    Ensembl 2494
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hacl1 No data available
    MARKER RELATIONSHIPS
    hacl1 Contained in: [BAC] CH211-227A6 (1)
    hacl1 Encodes: [EST] fd42e11 (1)
    [cDNA] MGC:76920 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213085 (1) 2467 nt
    Genomic GenBank:CR524826 (1) 136920 nt
    Select Tool
    Polypeptide UniProtKB:F1RB36 (1) 568 aa
    Sequence Information (all 12)
    ORTHOLOGY for hacl1 ( Chr: 16 )
    CITATIONS (24)