ZFIN ID: ZDB-GENE-040426-2003
Gene Name: glutamic-oxaloacetic transaminase 1, soluble
Gene Symbol: got1    Nomenclature History

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Previous Names: wu:fj63b09, zgc:55996

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have L-aspartate:2-oxoglutarate aminotransferase activity. Predicted to be involved in aspartate biosynthetic process. Predicted to localize to cytosol. Is expressed in retina. Human ortholog(s) of this gene implicated in amyloidosis; amyotrophic lateral sclerosis; pancreatic ductal adenocarcinoma; and transient cerebral ischemia. Orthologous to human GOT1 (glutamic-oxaloacetic transaminase 1).
Genome Resources: Alliance (1),  Gene:406330 (1),  Ensembl(GRCz11):ENSDARG00000039093 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12793 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH got1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Aspartate aminotransferase, serum level of, QTL1 614419
    DISEASE ASSOCIATED WITH got1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process biosynthetic process (more)
    Cellular Component cytosol (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA got1-201 (1)    Ensembl 666
    ncRNA got1-002 (1)    Ensembl 539
    got1-003 (1)    Ensembl 819
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM got1 No data available
    MARKER RELATIONSHIPS
    got1 Contained in: [BAC] CH73-49K17 (1), CH211-113D13
    got1 Encodes: [EST] fj63b09 (1)
    [cDNA] MGC:55996 (1), MGC:174088 (1), MGC:191961 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213057 (1) 3213 nt
    Genomic GenBank:BX005330 181197 nt
    Select Tool
    Polypeptide UniProtKB:Q7ZUW8 (1) 410 aa
    Sequence Information (all 24)
    ORTHOLOGY for got1 ( Chr: 13 )
    CITATIONS (33)