ZFIN ID: ZDB-GENE-040426-1977
Gene Name: ring finger protein 185
Gene Symbol: rnf185    Nomenclature History

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Previous Name: zgc:73070 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have ubiquitin protein ligase activity and ubiquitin-like protein conjugating enzyme binding activity. Predicted to be involved in ER-associated misfolded protein catabolic process and ubiquitin-dependent protein catabolic process. Predicted to localize to the Derlin-1 retrotranslocation complex. Is expressed in olfactory placode and peripheral olfactory organ. Orthologous to human RNF185 (ring finger protein 185).
Genome Resources: Alliance (1),  Gene:406310 (1),  Ensembl(GRCz11):ENSDARG00000032997 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 4 figures (5 images) from Thisse et al., 2004 [MGC:73070]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb290 Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • ihb291 Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-rnf185 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH rnf185 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH rnf185 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process autophagy (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR017907 Zinc finger, RING-type, conserved site
    Domain IPR001841 Zinc finger, RING-type
    Domain IPR018957 Zinc finger, C3HC4 RING-type
    Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript rnf185-202 (1)    Ensembl 933
    mRNA rnf185-201 (1)    Ensembl 952
    ncRNA rnf185-002 (1)    Ensembl 334
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rnf185 No data available
    MARKER RELATIONSHIPS
    rnf185 Contained in: [BAC] CH73-324K12 (1)
    [Fosmid] ZFOS-128G4 (1)
    rnf185 Encodes: [EST] fa31e09 (1)
    [cDNA] MGC:73070 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213037 (1) 944 nt
    Genomic GenBank:FP102032 (1) 87942 nt
    Select Tool
    Polypeptide UniProtKB:Q6PC78 (1) 194 aa
    Sequence Information (all 15)
    ORTHOLOGY for rnf185 ( Chr: 5 )
    CITATIONS (24)