ZFIN ID: ZDB-GENE-040426-1957
Gene Name: glutaredoxin 5 homolog (S. cerevisiae)
Gene Symbol: glrx5    Nomenclature History

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Previous Names: grx5 (1), glutaredoxin 5, id:ibd5119 (1), shiraz, shz, wu:fa09g08, zgc:73343

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have glutathione disulfide oxidoreductase activity. Involved in hemopoiesis and iron-sulfur cluster assembly. Localizes to the mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive pyridoxine-refractory sideroblastic anemia 3. Is expressed in cardiovascular system; immature eye; intermediate cell mass of mesoderm; and liver. Orthologous to human GLRX5 (glutaredoxin 5).
Genome Resources: Alliance (1),  Gene:406294 (1),  Ensembl(GRCz11):ENSDARG00000043665 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Directly Submitted Expression Data: 2 figures (4 images) from Kudoh et al., 2001 [ibd5119]
Wild-type Stages, Structures: Segmentation:10-13 somites (14.0h-16.0h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la021374Tg Transgenic Insertion Unknown Unknown DNA
sa6617 Point Mutation Unknown Premature Stop ENU
t22802 Unknown Unknown Unknown
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-glrx5 N/A 2
    MO2-glrx5 N/A 2
    DISEASE ASSOCIATED WITH glrx5 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive pyridoxine-refractory sideroblastic anemia 3 Alliance Anemia, sideroblastic, 3, pyridoxine-refractory 616860
    Spasticity, childhood-onset, with hyperglycinemia 616859
    DISEASE ASSOCIATED WITH glrx5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hemopoiesis (more)
    Cellular Component cytoplasm (more)
    Molecular Function 2 iron, 2 sulfur cluster binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR002109 Glutaredoxin
    Family IPR004480 Monothiol glutaredoxin-related
    Family IPR014434 Monothiol glutaredoxin
    Domain IPR033658 Glutaredoxin, PICOT-like
    Homologous_superfamily IPR036249 Thioredoxin-like superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA glrx5-201 (1)    Ensembl 892
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM glrx5 No data available
    MARKER RELATIONSHIPS
    glrx5 Contained in: [BAC] CH211-121D13
    glrx5 Encodes: [EST] fa09g08 (1), ibd5119
    [cDNA] MGC:73343 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213021 (1) 844 bp
    Genomic GenBank:AL845550 (1) 163676 bp
    Select Tool
    Polypeptide UniProtKB:Q6PBM1 (1) 155 aa
    Sequence Information (all 14)
    ORTHOLOGY for glrx5 ( Chr: 20 )
    CITATIONS (33)