Gene

srsf1a

ID

ZDB-GENE-040426-1950

Name

serine and arginine rich splicing factor 1a

Symbol

srsf1a Nomenclature History

Previous Names

sfrs1a
sfrs1l (1)
wu:fb52g10
wu:fb97g12
zgc:66146

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to have RNA binding activity. Predicted to be involved in mRNA cis splicing, via spliceosome and regulation of alternative mRNA splicing, via spliceosome. Predicted to localize to nuclear speck. Orthologous to human SRSF1 (serine and arginine rich splicing factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:66146 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With srsf1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
neurodevelopmental disorder with dysmorphic facies and behavioral abnormalities	Alliance	Neurodevelopmental disorder with dysmorphic facies and behavioral abnormalities	620489

Associated With srsf1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000504	RNA recognition motif domain
Domain	IPR029538	Serine/arginine-rich splicing factor 1, RNA recognition motif 2
Domain	IPR034520	SRSF1, RNA recognition motif 1
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Nucleotide-binding alpha-beta plait domain superfamily	RNA-binding domain superfamily	RNA recognition motif domain	Serine/arginine-rich splicing factor 1, RNA recognition motif 2	SRSF1, RNA recognition motif 1
UniProtKB:Q7SXP4 InterPro	257

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	srsf1a-201 (1) Ensembl	Havana	2171 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	srsf1a-202 (1) Ensembl	Havana	770 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	srsf1a-203 (1) Ensembl	Havana	543 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	srsf1a-003 (1) Ensembl	Havana	643 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations