Gene

chn1

ID
ZDB-GENE-040426-1934
Name
chimerin 1
Symbol
chn1 Nomenclature History
Previous Names
  • alpha chimerin (1)
  • wu:fr89a09
  • z-chimaerin (1)
  • zgc:56160
  • zgc:92906
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Exhibits GTPase activator activity and phorbol ester receptor activity. Involved in oculomotor nerve formation and positive regulation of GTPase activity. Is expressed in several structures, including central nervous system; digestive system; integument; pharyngeal arch; and testis. Human ortholog(s) of this gene implicated in Duane retraction syndrome. Orthologous to human CHN1 (chimerin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Clark et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With chn1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Duane retraction syndrome Alliance Duane retraction syndrome 2 604356
Associated With chn1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000198 Rho GTPase-activating protein domain
Domain IPR000980 SH2 domain
Domain IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain IPR020454 Diacylglycerol/phorbol-ester binding
Domain IPR035840 Chimaerin, SH2 domain
Domain IPR037860 Chimaerin, RhoGAP domain
Family IPR017356 Chimaerin
Homologous_superfamily IPR008936 Rho GTPase activation protein
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length Chimaerin Chimaerin, RhoGAP domain Chimaerin, SH2 domain Diacylglycerol/phorbol-ester binding Protein kinase C-like, phorbol ester/diacylglycerol-binding domain Rho GTPase-activating protein domain Rho GTPase activation protein SH2 domain SH2 domain superfamily
UniProtKB:Q5XIX9 334
UniProtKB:Q49NY1 459
UniProtKB:Q7ZUT6 459
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations