ZFIN ID: ZDB-GENE-040426-1918
Gene Name: hypoxanthine phosphoribosyltransferase 1
Gene Symbol: hprt1    Nomenclature History

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Previous Names: id:ibd1344, id:ibd5108, wu:fc10g09, zgc:56221 (1), zgc:86608

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have hypoxanthine phosphoribosyltransferase activity and magnesium ion binding activity. Predicted to be involved in hypoxanthine metabolic process and purine-containing compound salvage. Predicted to localize to cytoplasm. Is expressed in several structures, including digestive system; immature eye; midbrain; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Lesch-Nyhan syndrome. Orthologous to human HPRT1 (hypoxanthine phosphoribosyltransferase 1).
Genome Resources: Alliance (1),  Gene:406259 (1),  Ensembl(GRCz11):ENSDARG00000008884 (1)
GENE EXPRESSION
All Expression Data: 8 figures from 5 publications
Directly Submitted Expression Data: 1 figure (2 images) from Kudoh et al., 2001 [ibd5108]
  2 figures (2 images) from Kudoh et al., 2001 [ibd1344]
Wild-type Stages, Structures: Blastula:Sphere (4.0h-4.33h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH hprt1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Lesch-Nyhan syndrome Alliance Lesch-Nyhan syndrome 300322
HPRT-related gout 300323
DISEASE ASSOCIATED WITH hprt1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process IMP salvage (more)
Cellular Component cytoplasm (more)
Molecular Function guanine phosphoribosyltransferase activity (more)
GO Terms (all 15)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
aberrant processed transcript hprt1-201 (1)    Ensembl 1706
mRNA hprt1-202 (1)    Ensembl 3577
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM hprt1 No data available
MARKER RELATIONSHIPS
hprt1 Contained in: [BAC] DKEY-100E19 (1) (order this)
hprt1 Encodes: [EST] fc10g09, ibd1344 (1), ibd5108
[cDNA] MGC:56221 (1), MGC:86608 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_212986 (1) 1724 nt
Genomic GenBank:BX511227 (1) 262038 nt Blast at MegaBLAST
Polypeptide UniProtKB:A0A2R8QRE7 (1) 220 aa
Sequence Information (all 19)
ORTHOLOGY for hprt1 ( Chr: 14 )
CITATIONS (75)