Gene

gne

ID
ZDB-GENE-040426-1848
Name
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Symbol
gne Nomenclature History
Previous Names
  • zgc:77657 (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Exhibits UDP-N-acetylglucosamine 2-epimerase activity. Involved in chordate embryonic development; locomotion; and muscle fiber development. Is expressed in digestive system; muscle; nervous system; and somite border. Human ortholog(s) of this gene implicated in sialuria. Orthologous to human GNE (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase).
Genome Resources
Note
None
Expression
All Expression Data
Fig. 1 from Daya et al., 2014
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Daya et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gne Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
GNE myopathy Alliance Nonaka myopathy 605820
sialuria Alliance Sialuria 269921
Associated With gne Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003331 UDP-N-acetylglucosamine 2-epimerase domain
Family IPR000600 ROK family
Family IPR020004 UDP-N-acetylglucosamine 2-epimerase,UDP-hydrolysing
Family IPR029767 UDP-N-acetylglucosamine 2-epimerase WecB-like
Domain Details Per Protein
Protein Length ROK family UDP-N-acetylglucosamine 2-epimerase domain UDP-N-acetylglucosamine 2-epimerase,UDP-hydrolysing UDP-N-acetylglucosamine 2-epimerase WecB-like
UniProtKB:A0A0R4II12 748
UniProtKB:A0A0R4IPP1 732
UniProtKB:Q6P3K2 725
UniProtKB:A0A0J9YJ93 213
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations