Gene

grhprb

ID

ZDB-GENE-040426-1847

Name

glyoxylate reductase/hydroxypyruvate reductase b

Symbol

grhprb Nomenclature History

Previous Names

fb80f04
wu:fb80f04
zgc:77636

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have glycerate dehydrogenase activity; glyoxylate reductase (NADP) activity; and hydroxypyruvate reductase activity. Predicted to be involved in oxidation-reduction process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Is expressed in liver; pronephric duct; pronephros; and yolk syncytial layer. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:77636 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With grhprb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary hyperoxaluria type 2	Alliance	Hyperoxaluria, primary, type II	260000

Associated With grhprb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR029752	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1
Conserved_site	IPR029753	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
Domain	IPR006139	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Domain	IPR006140	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily

Domain Details Per Protein

Protein	Length	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1	NAD(P)-binding domain superfamily
UniProtKB:E9QCX2 InterPro	351
UniProtKB:Q6P0V7 InterPro	336
UniProtKB:F1QYH7 InterPro	361

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	grhprb-201 (1) Ensembl	Havana	1276 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	grhprb-202 (1) Ensembl	Havana	733 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	grhprb-205 (1) Ensembl	Havana	2454 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	grhprb-004 (1) Ensembl	Havana	426 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	grhprb-006 (1) Ensembl	Havana	1068 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations