Gene
plxnd1
- ID
- ZDB-GENE-040426-1828
- Name
- plexin D1
- Symbol
- plxnd1 Nomenclature History
- Previous Names
-
- obd
- out of bounds
- zgc:77379
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have semaphorin receptor activity. Involved in blood vessel morphogenesis and embryonic eye morphogenesis. Predicted to localize to integral component of membrane and plasma membrane. Is expressed in lateral mesoderm; pharyngeal arch 3-7; vascular cord; and vasculature. Orthologous to human PLXND1 (plexin D1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 26 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Congenital heart defects, multiple types, 9 | 620294 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001627 | Sema domain |
| Domain | IPR002909 | IPT domain |
| Domain | IPR013548 | Plexin, cytoplasmic RasGAP domain |
| Domain | IPR016201 | PSI domain |
| Domain | IPR041019 | Plexin, TIG domain 1 |
| Domain | IPR042719 | Plexin-D1, sema domain |
| Domain | IPR046800 | Plexin, cytoplasmic RhoGTPase-binding domain |
| Family | IPR031148 | Plexin family |
| Homologous_superfamily | IPR008936 | Rho GTPase activation protein |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036352 | Sema domain superfamily |
| Repeat | IPR002165 | Plexin repeat |
Domain Details Per Protein
| Protein | Length | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | Plexin, cytoplasmic RasGAP domain | Plexin, cytoplasmic RhoGTPase-binding domain | Plexin-D1, sema domain | Plexin family | Plexin repeat | Plexin, TIG domain 1 | PSI domain | Rho GTPase activation protein | Sema domain | Sema domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7FGF3
|
752 | ||||||||||||||
|
UniProtKB:Q6DSU3
|
1880 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available