Gene
cfl2
- ID
- ZDB-GENE-040426-1815
- Name
- cofilin 2 (muscle)
- Symbol
- cfl2 Nomenclature History
- Previous Names
-
- zgc:77288
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have actin filament binding activity. Predicted to be involved in actin filament fragmentation; actin filament severing; and cell motility. Predicted to localize to actin cytoskeleton and cytoplasm. Is expressed in lens; myotome; solid lens vesicle; and somite. Human ortholog(s) of this gene implicated in nemaline myopathy 7. Orthologous to human CFL2 (cofilin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6909063 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nemaline myopathy 7 | Alliance | Nemaline myopathy 7, autosomal recessive | 610687 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Actin-depolymerising factor homology domain | ADF/Cofilin | ADF-H/Gelsolin-like domain superfamily |
|---|---|---|---|---|
|
UniProtKB:Q6NZW3
|
166 |
Interactions and Pathways
No data available
Plasmids
No data available