ZFIN ID: ZDB-GENE-040426-1815
Gene Name: cofilin 2 (muscle)
Gene Symbol: cfl2    Nomenclature History

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Previous Name: zgc:77288

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity. Predicted to be involved in actin filament fragmentation and cell motility. Predicted to localize to cortical actin cytoskeleton. Is expressed in lens; myotome; solid lens vesicle; and somite. Human ortholog(s) of this gene implicated in nemaline myopathy 7. Orthologous to human CFL2 (cofilin 2).
Genome Resources: Alliance (1),  Gene:403001 (1),  Ensembl(GRCz11):ENSDARG00000014106 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 5 figures (4 images) from Thisse et al., 2004 [IMAGE:6909063]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Hatching:Long-pec (48.0h-60.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH cfl2 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
nemaline myopathy 7 Alliance Nemaline myopathy 7, autosomal recessive 610687
DISEASE ASSOCIATED WITH cfl2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process actin filament depolymerization (more)
Cellular Component actin cytoskeleton (more)
Molecular Function actin binding (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA cfl2-201 (1)    Ensembl 2768
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM cfl2 No data available
MARKER RELATIONSHIPS
cfl2 Contained in: [BAC] CH73-32G17 (1)
cfl2 Encodes: [EST] IMAGE:6909063 (1), fc42e05 (1)
[cDNA] MGC:77288 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_205700 (1) 2820 nt
Genomic GenBank:CU928207 (1) 47906 nt
Select Tool
Polypeptide UniProtKB:Q6NZW3 (1) 166 aa
Sequence Information (all 12)
ORTHOLOGY for cfl2 ( Chr: 17 )
CITATIONS (26)