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General Information
ZIRC
ZFIN ID: ZDB-GENE-040426-1808
Gene Name: transmembrane protein 88 a
Gene Symbol: tmem88a    Nomenclature History

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Previous Name: zgc:77242

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have PDZ domain binding activity. Involved in myeloid cell differentiation; negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment; and primitive hemopoiesis. Predicted to localize to the plasma membrane. Is expressed in blood cell; cardiovascular system; and mesoderm. Orthologous to human TMEM88 (transmembrane protein 88).
Genome Resources: Alliance (1),  Gene:402969 (1),  Ensembl(GRCz11):ENSDARG00000056920 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fci400 Small Deletion Exon 2 Frameshift, Premature Stop TALEN
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-tmem88a
1
CRISPR2-tmem88a
1
MO1-tmem88a N/A 3
MO2-tmem88a N/A 2
MO3-tmem88a N/A 1
MO4-tmem88a N/A 1
TALEN1-tmem88a 1
DISEASE ASSOCIATED WITH tmem88a HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH tmem88a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process myeloid cell differentiation (more)
Cellular Component integral component of membrane (more)
Molecular Function PDZ domain binding (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR033354 (1)
  • InterPro:IPR033355 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tmem88a-201 (1)    Ensembl 1301
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM tmem88a No data available
    MARKER RELATIONSHIPS
    tmem88a Contained in: [BAC] CH211-237L4 (1) (order this)
    tmem88a Encodes: [cDNA] MGC:77242 (1) (order this), MGC:173934 (1) (order this), MGC:173935 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_205670 (1) 1248 bp
    Genomic GenBank:AL807389 (1) 143672 bp
    Select Tool
    Polypeptide UniProtKB:F1QYI4 (1) 219 aa
    Sequence Clusters UniGene:89035 (1)
    Sequence Information (all 19)
    ORTHOLOGY for tmem88a ( Chr: 10 )
    CITATIONS (27)