ZFIN ID: ZDB-GENE-040426-1806
Gene Name: family with sequence similarity 126 member A
Gene Symbol: fam126a    Nomenclature History

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Previous Names: hyccin (1), zgc:77228

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to be involved in myelination; phosphatidylinositol phosphorylation; and protein localization to plasma membrane. Predicted to localize to cytosol and plasma membrane. Is expressed in habenula and telencephalon. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 5. Orthologous to human FAM126A (family with sequence similarity 126 member A).
Genome Resources: Alliance (1),  Gene:402926 (1),  Ensembl(GRCz11):ENSDARG00000026762 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 7 figures (15 images) from Thisse et al., 2004 [MGC:77228]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa8406 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15394 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH fam126a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hypomyelinating leukodystrophy 5 Alliance Leukodystrophy, hypomyelinating, 5 610532
    DISEASE ASSOCIATED WITH fam126a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process myelination (more)
    Cellular Component cytosol (more)
    Molecular Function molecular_function (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fam126a-201 (1)    Ensembl 2646
    fam126a-202 (1)    Ensembl 781
    fam126a-203 (1)    Ensembl 434
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fam126a No data available
    MARKER RELATIONSHIPS
    fam126a Contained in: [BAC] CH73-24K9 (1), CH73-345F18 (1)
    [Fosmid] CH1073-174I23 (1)
    fam126a Encodes: [cDNA] MGC:77228 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_205630 (1) 2648 nt
    Genomic GenBank:CU928128 (1) 107346 nt
    Select Tool
    Polypeptide UniProtKB:Q6P121 (1) 518 aa
    Sequence Information (all 23)
    ORTHOLOGY for fam126a ( Chr: 19 )
    CITATIONS (22)