ZFIN ID: ZDB-GENE-040426-1757
Gene Name: guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a
Gene Symbol: gnao1a    Nomenclature History

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Previous Names: gnao1, Galpha o1 (1), wu:fq26h05, zgc:73315

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway and dopamine receptor signaling pathway. Predicted to localize to heterotrimeric G-protein complex. Is expressed in gill; nervous system; neural rod; and trigeminal placode. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 17. Orthologous to human GNAO1 (G protein subunit alpha o1).
Genome Resources: Alliance (1),  Gene:393760 (1),  Ensembl(GRCz11):ENSDARG00000016676 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010490Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la020333Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45638 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gnao1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    early infantile epileptic encephalopathy 17 Alliance Epileptic encephalopathy, early infantile, 17 615473
    Neurodevelopmental disorder with involuntary movements 617493
    DISEASE ASSOCIATED WITH gnao1a VIA EXPERIMENTAL MODELS No data available
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gnao1a-201 (1)    Ensembl 2401
    gnao1a-202 (1)    Ensembl 1089
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gnao1a No data available
    MARKER RELATIONSHIPS
    gnao1a Contained in: [BAC] CH211-261E11 (1), CH211-262P15 (1), DKEY-3L5 (1) (order this)
    gnao1a Encodes: [EST] eu90 (1), fq26h05 (1) (order this)
    [cDNA] MGC:73315 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200787 (1) 2412 nt
    Genomic RefSeq:NW_018395026 (1) Blast at MegaBLAST
    Polypeptide UniProtKB:F8W442 (1) 354 aa
    Sequence Information (all 20)
    ORTHOLOGY for gnao1a ( Chr: 18 )
    CITATIONS (36)