Gene

xrcc4

ID

ZDB-GENE-040426-1755

Name

X-ray repair complementing defective repair in Chinese hamster cells 4

Symbol

xrcc4 Nomenclature History

Previous Names

zgc:73312 (1)

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to have DNA binding activity. Predicted to be involved in DNA metabolic process; positive regulation of ligase activity; and response to X-ray. Predicted to localize to DNA ligase IV complex and DNA-dependent protein kinase-DNA ligase 4 complex. Human ortholog(s) of this gene implicated in multiple myeloma. Orthologous to human XRCC4 (X-ray repair cross complementing 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:73312 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With xrcc4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Short stature, microcephaly, and endocrine dysfunction	616541

Associated With xrcc4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR010585	DNA repair protein XRCC4
Homologous_superfamily	IPR009089	XRCC4, N-terminal domain superfamily
Homologous_superfamily	IPR014751	DNA repair protein XRCC4-like, C-terminal
Homologous_superfamily	IPR038051	XRCC4-like, N-terminal domain superfamily