ZFIN ID: ZDB-GENE-040426-1737
Gene Name: coiled-coil-helix-coiled-coil-helix domain containing 2
Gene Symbol: chchd2    Nomenclature History

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Previous Names: chchd2l, zgc:73266 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have sequence-specific DNA binding activity. Predicted to be involved in mitochondrion organization and positive regulation of transcription by RNA polymerase II. Predicted to localize to mitochondrion and nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease 22. Orthologous to human CHCHD2 (coiled-coil-helix-coiled-coil-helix domain containing 2).
Genome Resources: Alliance (1),  Gene:393740 (1),  Ensembl(GRCz11):ENSDARG00000059304 (1)
GENE EXPRESSION
All Expression Data: Fig. 5 from Babu et al., 2016
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa35803 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH chchd2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Parkinson's disease 22 Alliance Parkinson disease 22, autosomal dominant 616710
    DISEASE ASSOCIATED WITH chchd2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process mitochondrion organization (more)
    Cellular Component mitochondrion (more)
    Molecular Function sequence-specific DNA binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA chchd2-201 (1)    Ensembl 961
    chchd2-202 (1)    Ensembl 713
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM chchd2 No data available
    MARKER RELATIONSHIPS
    chchd2 Contained in: [BAC] CH211-195H6 (1)
    chchd2 Encodes: [cDNA] MGC:73266 (1), MGC:173983 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200767 (1) 917 nt
    Genomic GenBank:BX088654 (1) 205794 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8Q8S0 (1) 174 aa
    Sequence Information (all 14)
    ORTHOLOGY for chchd2 ( Chr: 15 )
    CITATIONS (19)