ZFIN ID: ZDB-GENE-040426-1712
Gene Name: guanine nucleotide binding protein (G protein), beta 5b
Gene Symbol: gnb5b    Nomenclature History

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Previous Names: gnb5, zgc:73196

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to contribute to GTPase activator activity. Predicted to be involved in G protein-coupled receptor signaling pathway; dopamine receptor signaling pathway; and positive regulation of GTPase activity. Predicted to localize to cytoplasm and heterotrimeric G-protein complex. Is expressed in cardiovascular system; cranial ganglion; neurons; and visual system. Orthologous to human GNB5 (G protein subunit beta 5).
Genome Resources: Alliance (1),  Gene:393719 (1),  Ensembl(GRCz11):ENSDARG00000055377 (2)
GENE EXPRESSION
All Expression Data: 13 figures from 2 publications
Directly Submitted Expression Data: 5 figures (8 images) from Thisse et al., 2004 [MGC:73196]
  7 figures (9 images) from Thisse et al., 2004 [IMAGE:6906816]
Wild-type Stages, Structures: Segmentation:10-13 somites (14.0h-16.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu11443 Indel Unknown Premature Stop CRISPR
sa10693 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36703 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-gnb5b 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gnb5b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Intellectual developmental disorder with cardiac arrhythmia 617173
    Language delay and ADHD/cognitive impairment with or without cardiac arrhythmia 617182
    DISEASE ASSOCIATED WITH gnb5b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process signal transduction (more)
    Cellular Component membrane (more)
    Molecular Function G-protein gamma-subunit binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gnb5b-201 (1)    Ensembl 2001
    gnb5b-202 (1)    Ensembl 634
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gnb5b No data available
    MARKER RELATIONSHIPS
    gnb5b Contained in: [BAC] CH211-235F12 (1)
    gnb5b Encodes: [EST] IMAGE:6906816 (1)
    [cDNA] MGC:73196 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200746 (1) 1794 nt
    Genomic GenBank:AL935189 (1) 170193 nt
    Select Tool
    Polypeptide UniProtKB:Q6PBY0 (1) 395 aa
    Sequence Information (all 11)
    ORTHOLOGY for gnb5b ( Chr: 18 )
    CITATIONS (31)